MIRATI THERAPEUTICS TO PRESENT PRE-CLINICAL AND INITIAL CLINICAL DATA FOR MRTX849, A KRAS G12C INHIBITOR, AT THE 2019 AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS

On October 17, 2019 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a clinical-stage targeted oncology company, reported it will present pre-clinical data and initial clinical data on MRTX849, a novel and optimized KRAS G12C inhibitor, in presentations at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) in Boston, October 26-30, 2019 at the Hynes Convention Center (Press release, Mirati, OCT 17, 2019, View Source [SID1234542337]).

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On Monday, October 28, beginning at 4:20pm EDT, pre-clinical MRTX849 data will be presented in an oral presentation, "The KRAS G12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers" during "Concurrent Session 5: Targeting the RAS/MAP Kinase Pathway" by Dr. James Christensen, Ph.D., Executive Vice President and Chief Scientific Officer at Mirati. Following the pre-clinical presentation, MRTX849-001 Investigator, Dr. Pasi A. Janne, M.D., Ph.D., Director of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute, Professor of Medicine, Harvard University and the Scientific Director of the Belfer Center for Applied Cancer Science will highlight initial clinical data for MRTX849 in an oral presentation, "A Phase 1 Clinical Trial Evaluating the Pharmacokinetics (PK), Safety, and Clinical Activity of MRTX849, a Mutant-Selective Small Molecule KRAS G12C Inhibitor, in Advanced Solid Tumors".

POSTER PRESENTATIONS

Additionally, MRTX849 pre-clinical data will be presented in two poster presentations.

Poster Title: Discovery and Pre-Clinical Development of MRTX849: A Mutation-Selective KRAS G12C Inhibitor
Session Title: Therapeutic Agents: Other
Session Date: Tuesday, October 29, 2019
Session Start Time: 12:30pm EDT
Session End Time: 4:00pm EDT
Location: Hall D, Hynes Convention Center
Abstract/Poster Number: C069

Poster Title: The KRAS G12C inhibitor MRTX849 reconditions the tumor immune microenvironment and leads to durable complete responses in combination with anti-PD-1 therapy in a syngeneic mouse model
Session Title: Late-Breaking Poster Session C: Therapeutic Agents: Other
Session Date: Tuesday, October 29, 2019
Session Start Time: 12:30pm EDT
Session End Time: 4:00pm EDT
Location: Hall D, Hynes Convention Center
Board Number: 156
Abstract/Poster Number: LB-C09

About MRTX849

MRTX849 is an investigational, orally-available small molecule that is designed to potently and selectively inhibit a form of KRAS which harbors a substitution mutation (G12C). KRAS G12C mutations are present in approximately 14% of NSCLC adenocarcinoma patients, 4% of colorectal cancer patients, and subsets of other types of cancer. Tumors characterized by KRAS G12C mutations are commonly associated with poor prognosis and resistance to therapy, and patients with these mutations have few treatment options. MRTX849 is being evaluated in a Phase 1/2 trial treating patients with molecularly-identified, KRAS G12C-positive advanced solid tumors.