On November 13, 2013 Merck Serono (Merck KGaA) reported that a global licensing, co-development, and commercialization agreement for BeiGene-290 has been signed with BeiGene (Press release BeiGene, NOV 13, 2013, View Source [SID:1234500416]).
The compound, which is a potent poly (ADP-ribose) polymerase (PARP) inhibitor for the treatment of cancer, is currently in preclinical development and is expected to enter clinical development next year. This is the second collaboration agreement between the two companies this year.
PARP inhibitors are thought to target an enzyme family, poly (ADP-ribose) polymerase, which is involved in a number of cellular processes, including DNA repair and programmed cell death.
Under the terms of the collaboration, BeiGene will be responsible for the development and commercialization of BeiGene-290 in China, and Merck will be responsible for the development and commercialization of BeiGene-290 for the rest of the world. BeiGene will receive an undisclosed upfront payment and is eligible to receive further payments of up to € 170 million (US$ 232 million) for the achievement of clinical developmentand potential commercial milestones in both the People’s Republic of China and rest of the world, as well as royalties on net sales.

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