On June 1, 2023 Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported its pipeline expansion into neoantigens (also known as oncogenic driver mutations) with KRAS (Kirsten rat sarcoma viral oncogene homologue) as the first target in its MDG10xx program, a T cell receptor engineered T cell (TCR-T) therapy being developed in combination with the company’s PD1-41BB switch receptor technology (Press release, MediGene, JUN 1, 2023, View Source [SID1234632361]). The first KRAS antigens and HLAs (human leukocyte antigens) of the library announced today are targeting:

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KRAS G12V-A11 (MDG2011)
KRAS G12V-A03 (MDG2012)
KRAS G12D-A11 (MDG2021)

Neoantigens are tumor-specific antigens (TSA) and play a critical role in the growth of tumors. These mutations are found in many solid tumors and their prevalence varies depending on the cancer type. KRAS mutations are widely recognized as the most common oncogene mutations in difficult-to-treat solid tumors existing in ~30% of solid tumors, such as pancreatic, colorectal, endometrial and non-small-cell lung cancer. Global incidence of solid tumors expressing KRAS mutations is estimated to be in excess of 300,000 patients.

"Our pipeline expansion into neoantigens with multiple KRAS targets represents a major advance in our pursuit to develop best-in-class TCR-T therapies for patients suffering from difficult-to-treat solid tumors," said Dr. Selwyn Ho, Chief Executive Officer at Medigene. "We are delighted that this latest milestone continues to validate Medigene’s proprietary end-to-end platform as the basis for our highly specific, sensitive and potentially safer TCRs with optimal affinity. These TCRs will be combined with the PD1-41BB and/or the CD40L-CD28 costimulatory switch receptors to enhance the proliferation and persistence of the TCR-T cells and to help mitigate the immunosuppressive effects of the tumor microenvironment."

Dr. Ho continued, "We confirm our guidance to announce the first lead candidate for MDG10XX, which has been renamed as MDG2011, in Q3 this year and expect to announce new TCRs in the near future as we build the broadest KRAS library possible."

R&D Event

The Company will host an R&D Event to discuss the pipeline expansion and the evolution of its end-to-end platform on Tuesday, June 20, 2023, at 10:00 am ET. A Q&A session will follow the formal presentations and discussions.

Full details for the webcast and registration are as follows:

Date: June 20, 2023
Time: 10:00 am ET
Location: Virtual
Webcast registration: View Source
Following the call, an archived webcast will also be accessible on the Investor & Media section of the Medigene website View Source