On December 7, 2021 Massive Bio, a leader in precision medicine and artificial intelligence (AI)-enabled patient-centric clinical trial enrollment for oncology reported the launch of its 100K CANCER CLINICAL TRIAL SINGULARITY PROGRAM, a first-of-its-kind program aimed to provide real-time access to cutting-edge clinical trials for cancer patients globally (Press release, Massive Bio, DEC 7, 2021, View Source [SID1234596556]).
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A recent analysis from the National Cancer Database (NCDB) looking at patients enrolled in clinical trials as their initial course of treatment for 46 cancers from 2004 through 2015 found that out of over 12 million patients, less than 0.1% were enrolled in trials. The analysis also importantly revealed that patients with cancer treated in clinical trials lived longer than those not treated in trials. "We can and must do much better than that, using data, technology and services that are laser-focused on targeted therapies and immunotherapies while drastically increasing diversity and inclusion" mentioned Arturo Loaiza-Bonilla, M.D., Co-Founder of Massive Bio. "We named the program singularity because the clinical research industry needs transformational change on an exponential scale to effect a quantifiable increase in clinical trial enrollment rates. Otherwise, we will be discussing the same issues in the decades to come," added Loaiza-Bonilla.
"This is our calling. We have been planning this moment for a very long time. We are building and leading the Amazonization of the patient enrollment value chain in oncology. Everything is about efficiency and scale, and we are engineering every component of the value chain with extreme precision and accuracy. We are building the pieces of the puzzle – we have on-boarded 33,000 patients, partnered with 24 pharmaceutical companies, CROs and health systems, hit 1,000 clinical trial sites, and launched the world’s first NASA-style Oncology Clinical Trial Command Center (OCTCC). Now, it is time to activate more patients and enterprise partners to hit critical mass so that there is no going back. As much as we are taking the lead, we are looking forward to collaboration. What is more impressive is that we are providing services to cancer patients for free globally so that anyone can join this movement" said Selin Kurnaz, Co-Founder and CEO.
To achieve 100K patients, Massive Bio has gone through innovative patient acquisition partnerships globally with more than two dozen patient advocacy groups, data driven patient identification companies, provider networks, NGS vendors, payers, specialty pharmacies and local CROs. The company is on target to double its footprint and operationalize in 19 countries within a year.
The 100K SINGULARITY program initially focuses on Lung, Cervical, Breast, Prostate, Gastric, GE Junction, and Pancreatic cancer, as well as Non-Hodgkin Lymphoma, Myelofibrosis, CNS tumors, Pediatric Tumors, Melanoma, Multiple Myeloma, and cancers driven by potentially actionable biomarkers such as gene fusions, and will continue to expand to other malignancies. The new catalog of clinical trial matching solutions will be made available to cancer patients globally, through its website and Apps across iOS and Android.
"Technology is key. We have been working on developing AI models to structure clinical, genomic, and clinical trial information over the past few years to match cancer patients to clinical trials and make patients aware of clinical trials without the need to go to a site. Moreover, we have been spending a significant amount of time integrating various patient identification data to precisely target patient populations – as data is still siloed even with partnerships. All these credentials have positioned us to be the only company to use an AI-integrated mobile app that finds eligible clinical trials with confidence, as well as refer patients to the closest sites once the trial is available for them. The efficiency is astronomical. We are reducing the time of pre-screening from days to minutes. With the addition of our new COO and his expertise in streamlining and scaling operations, Massive Bio’s operations and technology architecture is ready to take on 100K patients. We couldn’t be more excited" said Massive Bio’s Co-founder and Chief Technology Officer (CTO) Cagatay Culcuoglu.
The company says that with close to 14,000 actively recruiting interventional cancer clinical trials globally at any given time, and over 18 million patients being diagnosed with cancer every year, this program will not only provide improved outcomes for cancer patients, but also provide faster drug development and more efficient patient enrollment to pharmaceutical companies, biotechs, CROs and clinical research sites.
The new initiative comes only a few months after Massive Bio successfully implemented its Phase I National Cancer Institute (NCI) SBIR to develop and characterize its Deep Learning Clinical Trial Matching System (DLCTMS) at Columbia’s Herbert Irving Comprehensive Cancer Center.
"Massive Bio is building bridges among all stakeholders in the patient enrollment value chain to hit 100K patient targets. This is just the beginning of a multi-year commitment and a new era. We hope every patient, provider, pharmaceutical company, payer and NGS vendor will join this movement. The clock is ticking, and the time is now" concluded Massive Bio’s Chief Operating Officer (COO), Steve McNamara.