On March 12, 2024 Ratio Therapeutics Inc. (Ratio), an emerging pharmaceutical company employing innovative technologies to develop best-in-class radiopharmaceuticals for cancer treatment and monitoring, reported an expanded manufacturing agreement with PharmaLogic, a world-class contract development and manufacturing organization (CDMO) specializing in radiopharmaceutical production and distribution (Press release, Ratio Therapeutics, MAR 12, 2024, View Source [SID1234641054]). The collaboration aims to significantly accelerate the development and commercialization of Ratio’s pipeline of next-generation radiotherapies, representing a critical component in advancing Ratio’s fibroblast activation protein-alpha (FAP)-targeted radiotherapeutic candidate.
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"We are excited to partner with PharmaLogic, an industry-leading CDMO with over 15 years of experience in radiopharmaceutical manufacturing and supply chain solutions" said Dr. Matthias Friebe, Chief Technology Officer of Ratio. "With advanced facilities, substantial capacity, and an impressive track record of quality and compliance, PharmaLogic has demonstrated their ability to reliably produce highly complex radiopharmaceutical products. Their expertise in sophisticated technologies such as accelerated radiochemistry and automation will ensure efficient, scalable production of our novel pipeline therapies to meet future commercial demands. This collaboration represents a major step towards Ratio Therapeutics’ mission of discovering and rapidly transitioning innovative radiopharmaceuticals to the clinic, aiming to transform treatment paradigms and improve patient outcomes."
"We are honored to collaborate with Ratio Therapeutics and support their pipeline of precision-targeted radiotherapies," said D. Scott Holbrook, Chief Strategy Officer and General Manager at PharmaLogic. "Ratio is at the forefront of developing radiopharmaceutical solutions that have the potential to significantly improve patient outcomes. By leveraging our combined expertise and manufacturing capabilities, we aim to make these cutting-edge therapies readily available to patients in need."
Ratio, in collaboration with Lantheus and PharmaLogic, is currently conducting a Phase I trial evaluating the efficacy of a novel FAP-targeted imaging biomarker, copper-64[Cu-64]-labeled LNTH-1363S (formerly RTX-1363S) for PET imaging in adult healthy volunteers. The company also recently announced a $50M Series B financing which will significantly drive the clinical advancement of Ratio’s first FAP-targeted therapeutic candidate into clinical trials this year.