On June 1, 2022 Manhattan BioSolutions, Inc., an emerging biotechnology company developing new classes of therapeutic biologics for the treatment of advanced and metastatic cancers, reported a multitarget research and development collaboration and license option agreement with Binghamton University (Press release, Manhattan BioSolutions, JUN 1, 2022, View Source [SID1234616177]). The collaboration will utilize novel immune-stimulatory linker-payload technology invented at Binghamton University to develop novel antibody-drug conjugates (ADCs) for oncology applications.
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The lead investigator is Dr. L. Nathan Tumey, an Assistant Professor in the School of Pharmacy and Pharmaceutical Sciences. Dr. Tumey is a world-class expert in linker-payload chemistry and ADC design, who joined Binghamton University following a long career as a medicinal chemist in the pharmaceutical industry, most recently at Pfizer. Manhattan BioSolutions will have an exclusive option to license global rights for selected linker-payload – antibody combinations targeting distinct tumor-associated antigens.
In addition to the collaboration, Dr Tumey has joined Manhattan BioSolutions’s Scientific Advisory Board.
Dr. Borys Shor, Chief Executive Officer, Manhattan BioSolutions commented: "This agreement comes as we continue to build out our preclinical pipeline of novel biologics. It enables us to combine our proprietary antibodies with non-cytotoxic payloads designed to specifically activate innate immune pathways in hematological or in solid tumors. Due to his expertise in medicinal chemistry, Dr Tumey’s laboratory will be a key partner to bringing innovative linker-payload technology into our development pipeline."
Dr. Tumey added: "We are excited to be partnering with Manhattan BioSolutions in order to advance a number of innovative preclinical immune-stimulating ADC programs. We believe that the combination of our proprietary ADC technology and Manhattan Biosolution’s novel tumor targeting antibodies will produce candidate medicines with unique biological properties. We are particularly excited about developing non-cytotoxic ADCs that may have an improved safety profile as compared to traditional ADC technology."