On July 26, 2021 Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, reported the Company will be presenting initial data from the DisTinGuish study, a Phase 2a clinical trial evaluating Leap’s anti-Dickkopf-1 (DKK1) antibody, DKN-01, in combination with tislelizumab, BeiGene’s Ltd.’s anti-PD-1 antibody, with or without chemotherapy, in patients with gastric or gastroesophageal junction cancer (G/GEJ), at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress, being held virtually on September 16-21, 2021 (Press release, Leap Therapeutics, JUL 26, 2021, View Source [SID1234585192]). The Company plans to host a conference call on Thursday, September 16, 2021 to further discuss the data.
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"We are pleased to have the opportunity to share initial data from the DisTinGuish study at ESMO (Free ESMO Whitepaper) in September," said Douglas E. Onsi, President and Chief Executive Officer of Leap. "We are encouraged by the potential DKN-01 has to improve response rates as part of first-line therapy for gastric and gastroesophageal junction cancer patients, particularly those patients whose tumors express high levels of DKK1, and look forward to providing additional details at this year’s congress."
Leap Presentation Details:
Title: DKN-01 in combination with tislelizumab and chemotherapy as a first-line therapy in unselected patients with advanced gastroesophageal adenocarcinoma (GEA): DisTinGuish Trial
Abstract Number: 2218
Session type: E-Poster Presentation
Presenter: Samuel J. Klempner, Harvard Medical School
Date and time: Thursday, September 16, 2021; 2:30 a.m. ET
About the DisTinGuish Study
The DisTinGuish study (NCT04363801) is a Phase 2a, non-randomized, open-label, multicenter study of DKN-01 in combination with tislelizumab, BeiGene Ltd.’s anti-PD-1 antibody, with or without chemotherapy as first-line or second-line therapy in adult patients with inoperable, locally advanced gastric or gastroesophageal junction cancer G/GEJ) adenocarcinoma. The study, which is being conducted in two parts in the United States and the Republic of Korea, completed enrollment of 25 patients with first-line G/GEJ cancer in April 2021 and will enroll up to 48 patients with second-line G/GEJ cancer whose tumors express high levels of DKK1. Leap is conducting this combination study as part of an exclusive option and license agreement with BeiGene for the development of DKN-01 in Asia (excluding Japan), Australia, and New Zealand.