On November 4, 2021 Lantern Pharma (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") platform to transform the cost, pace, and timeline of oncology drug discovery and development, reported that Lantern Pharma’s abstract on the effectiveness of LP-284 in hematologic cancers has been accepted as a poster at the upcoming 63rd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, which is being held in-person and virtually from December 11 – 14, 2021 (Press release, Lantern Pharma, NOV 4, 2021, View Source [SID1234594400]). The abstract is available online on the ASH (Free ASH Whitepaper) website.
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Abstract Title: The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers
Session Name: 802. Chemical Biology and Experimental Therapeutics: Poster III
Abstract Number: 3991
Poster Session Date & Time: Monday, December 13, 2021, 6:00 PM – 8:00 PM
Presenter: Jianli Zhou, Ph.D., Lantern Pharma
LP-284 is a fully synthetic molecule belonging to the new generation of acylfulvenes, a family of naturally derived anti-cancer drug candidates. While LP-184 shows potency in solid cancer, LP-284 was primarily developed as an analogue which shows selective efficacy against hematologic cancer. LP-284 is currently being evaluated for activity in a wide spectrum of hematological cancers.
Together with the work of collaborators, the roadmap to advancement of LP-284 to the clinic includes identification and validation of target indications, response gene signature development leading to IND-enabling pharmacokinetic profiling, and tolerability and dose range finding studies followed by clinical protocol development.