On June 1, 2019 Kymab, a clinical-stage biopharmaceutical company developing antibody-based therapeutics, reported a poster presentation detailing updates on the ongoing clinical trial of the company’s anti-ICOS program KY1044 at the 2019 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Press release, Kymab, JUN 1, 2019, View Source [SID1234537016]). The poster details the first-in-human clinical study (NCT03829501) of KY1044, Kymab’s fully human anti-ICOS IgG1 antibody. KY1044 is designed to both deplete intratumoral regulatory T cells and stimulate effector T cells to promote the immune response against tumors. The study was initiated in February of this year.
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Title: A first-in-human study of KY1044, a fully human anti-ICOS IgG1 antibody as monotherapy and in combination with atezolizumab in patients with selected advanced malignancies.
Presenter: Sonia Quaratino M.D. Ph.D., Chief Medical Officer, Kymab
Abstract #: TPS2644
Session Title: Developmental Immunotherapy and Tumor Immunobiology
Location: Hall A
Poster board #: 288a
Date and Time: Saturday June 1, 8:00 – 11:00 a.m. CT
"We are incredibly excited to be underway with our lead immune oncology program, which has shown very encouraging results in preclinical cancer models," said Sonia Quaratino, M.D., Ph.D., Chief Medical Officer of Kymab. "We look forward to the data that will be generated from these first studies exploring the potential synergy of our programs for the benefit of patients with advanced solid cancer."
The abstracts have been published on the ASCO (Free ASCO Whitepaper) website, and may be accessed via View Source
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Notes to Editors
Read the PDF version of the official release.
About the Study
NCT03829501 is a Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies. The dose escalation of KY1044 as a single agent commenced in February 2019.
For more information visit www.clinicaltrials.gov.
About KY1044
KY1044 is a fully human monoclonal antibody discovered by Kymab’s IntelliSelect Transgenics platforms. KY1044 has now been tested in a number of highly illustrative syngeneic models, in which KY1044 was observed to strongly inhibit tumor growth in cancers both as a monotherapy and in combination with other immunotherapies.
Inducible T Cell Co Stimulator (ICOS), is expressed upon activation on T cells and at high levels on the majority of FOXP3+ regulatory CD4+ T cells. Available data suggest that depletion of these immunosuppressive cells from the tumor microenvironment may enhance the patient’s anti-tumor immune response.