On April 28, 2025 Shanghai Juncell Therapeutics Co., Ltd. (Juncell Therapeutics), a clinical-stage biotech specializing in developing innovative IL-2-independent Tumor-Infiltrating Lymphocyte (TIL) therapies for cancer, reported it will present preclinical data on a feeder-free manufacturing process for IL-2-independent TIL expansion at the 28th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper), taking place May 13–15, 2025, in New Orleans, LA (Press release, Juncell Therapeutics, APR 28, 2025, View Source [SID1234652274]).
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The study highlights Juncell Therapeutics’ breakthroughs in TIL process development, demonstrating that its proprietary feeder-free system can generate robust, functional TILs from both "hot" and "cold" tumor tissues without relying on high-concentration interleukin-2 (IL-2). These TILs exhibited significant anti-tumor activity in syngeneic patient-derived organoid (PDO) and patient-derived xenograft (PDX) models. By eliminating IL-2 dependence and removing the need for feeder cells, the technology paves the way for safer TIL treatment regimens and reduces manufacturing costs.
Presentation Details:
Title: Development of A Feeder-Free Process for IL-2-Independent TIL Expansion
Poster Number: AMA362
Session: Thursday Poster Reception
Date and Time: May 15, 2025, 5:30 PM–7:00 PM
Location: Poster Hall Hall I2