On December 19, 2019 Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive biomarkers, reported that new data from the vopratelimab ICONIC trial, on the association of a predictive RNA signature with the emergence of ICOS hi CD4 T cells and clinical outcomes, will be presented at a poster session at the 2020 ASCO (Free ASCO Whitepaper)-SITC Clinical Immuno-Oncology Symposium Annual Meeting, being held February 6-8, 2020 in Orlando, Florida (Press release, Jounce Therapeutics, DEC 19, 2019, View Source [SID1234552507]).
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"We are pleased to present the new data that led to our selection of a predictive biomarker for our next vopratelimab trial. We believe patient selection strategies to identify patients more likely to respond to immuno-oncology therapies may better address unmet medical needs," said Elizabeth Trehu, M.D., chief medical officer of Jounce Therapeutics. "The potential predictive biomarker that we will present at ASCO (Free ASCO Whitepaper)-SITC is an RNA signature. In 2020, we plan to initiate the new Phase 2 predictive biomarker trial, which will study vopratelimab in combination with our investigational PD-1 inhibitor, JTX-4014, in RNA signature selected patients."
Poster Presentation Details
Title: Association of a predictive RNA signature (RS) with emergence of ICOS hi CD4 T cells and efficacy outcomes for the ICOS agonist vopratelimab (vopra) and nivolumab (nivo) in patients (pts) on the ICONIC trial
Author: Timothy A. Yap, M.B.B.S., Ph.D., M.R.C.P., B.S., The University of Texas MD Anderson Cancer Center
Session Title: Poster Session A
Abstract Number: 14
Session Date and Time: Thursday, February 6, 2020, 11:30 AM-1:00 PM and 6:00 PM-7:00 PM ET
About Vopratelimab
Jounce’s lead product candidate, vopratelimab (formerly JTX-2011), is a clinical-stage monoclonal antibody that binds to and activates ICOS, the Inducible T cell CO-Stimulator, a protein on the surface of certain T cells commonly found in many solid tumors. Vopratelimab is currently being assessed in the Phase 2 EMERGE clinical trial in sequence with ipilimumab in patients with non-small cell lung cancer (NSCLC) or urothelial cancer who were previously treated with PD-1/PD-L1 inhibitor therapies. Jounce is also planning to initiate a new predictive biomarker trial of vopratelimab with its investigational PD-1 inhibitor, JTX-4014, in RNA signature selected patients. Vopratelimab was previously assessed in the Phase 1/2 ICONIC trial and was found to be safe and well-tolerated, alone and in combination with each of the anti-PD-1 antibodies nivolumab and pembrolizumab, as well as with ipilimumab, an antibody that binds to CTLA-4. Jounce has previously presented data demonstrating the emergence of ICOS hi CD4 T cells in the peripheral blood in patients treated with vopratelimab alone or in combination with nivolumab, and has further shown that emergence of these cells, which is related to vopratelimab and not PD-1 inhibitors, is associated with improved response rate, progression free survival, and overall survival.