On December 1, 2022 Jacobio Pharma (1167.HK) reported that it will present the results of KRAS G12C inhibitor JAB-21822 as a single agent or in combination with SHP2 inhibitor JAB-3312 in preclinical cancer models in a poster session during the 2022 European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) ASIA (ESMO ASIA) Congress from December 2, 2022 to December 4, 2022 (Press release, Jacobio Pharmaceuticals, DEC 1, 2022, View Source [SID1234624708]).
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The results of preclinical study showed that JAB-21822 in combination with JAB-3312 could synergistically inhibit tumor growth in multiple KRAS G12C inhibitor-resistant models, suggesting that the combination of JAB-21822 and JAB-3312 may overcome adaptive resistance to KRAS G12C inhibitor in cancer patients. Jacobio is currently conducting a clinical trial of JAB-21822 in combination with JAB-3312 (ClinicalTrials.gov Identifier: NCT05288205).
About the Abstract:
Track: Developmental therapeutics
Title: Investigation of KRAS G12C inhibitor JAB-21822 as a single agent and in combination with SHP2 inhibitor JAB-3312 in preclinical cancer models
Format: Poster presentation
Abstract Number: 30P
Time: December 3, 2022
Please visit the official website of ESMO (Free ESMO Whitepaper) ASIA for more information: View Source
About JAB-21822
JAB-21822 is an oral, small molecule KRAS G12C inhibitor independently developed by the Company. The Company has initiated a number of Phase I/II clinical trials in China, the United States and Europe for patients harbouring KRAS G12C mutation with advanced solid tumors, including pivotal clinical trial to treat non-small cell lung cancer in China; monotherapy for STK11 co-mutated non-small cell lung cancer in the front-line setting; combination therapy with SHP2 inhibitor JAB-3312, anti-PD-1 monoclonal antibody and cetuximab.
About JAB-3312
JAB-3312 is a high-selective SHP2 allosteric inhibitor. Jacobio is currently conducting clinical trials of JAB-3312 in China and the United States, and JAB-3312 has been granted orphan drug designation for esophageal cancer (including esophageal squamous cell carcinoma) by the U.S. Food and Drug Administration (FDA). Jacobio has signed a global, strategic collaboration agreement to develop and commercialise SHP2 inhibitors with AbbVie on June 1, 2020.