On May 16, 2021 Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, metabolic, autoimmune, ophthalmology and other major diseases, reported that multiple clinical data in relation to TYVYT (sintilimab injection), pemigatinib (IBI375, FGFT1/2/3 inhibitor) and IBI110 (anti-LAG-3 monoclonal antibody) will be published at the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) annual meeting (Press release, Innovent Biologics, MAY 16, 2021, View Source [SID1234580075]). A brief summary of the studies is as follows:

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Cancer Type: Lung Cancer
Topic: Two-year Follow up of Single PD-1 Blockade in Neoadjuvant Resectable NSCLC.
Presentation Type: Poster
Abstract Number: 8522
Researcher: Professor Shugeng GAO, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Cancer Type: Colorectal Cancer
Topic: Preliminary results of a phase 1b study of fruquintinib plus sintilimab in advanced colorectal cancer
Presentation Type: Poster Discussion
Abstract Number: 2514
Researcher: Professor Ye Guo, Professor Jin Li, Shanghai East Hospital of Tongji University, Shanghai, China

* The study is jointly cooperated by Innovent and HUTCHMED (China) Limited.

Cancer Type: Advanced Malignancy
Topic: A phase 1 study evaluating preliminary safety, pharmacokinetic and pharmacodynamic of pemigatinib in Chinese patients with advanced malignancy.
Presentation Type: Abstract
Abstract Number: e15051
Researcher: Professor Yi Ba, Tianjin Medical University Cancer Hospital, Tianjin, China

Cancer Type: Solid Tumors
Topic: Phase Ia/Ib dose-escalation study of IBI110 (anti-LAG-3 mAb) as a single agent and in combination with sintilimab (anti-PD-1 mAb) in patients (pts) with advanced solid tumors
Presentation Type: Poster
Abstract Number: 334761
Researcher: Professor Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China; Professor Nong Xu, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China

Multiple independent investigators’ studies in relation to sintilimab aras the following:

Cancer Type: Cervical Cancer
Topic: Anlotinib plus sintilimab in patients with recurrent advanced cervical cancer: A prospective, multicenter, single-arm, phase II clinical trial.
Presentation Type: Poster Discussion
Abstract Number: 5524
Researcher: Professor Qin Xu, Fujian Cancer Hospital, Fujian, China

Cancer Type: Gastric Cancer
Topic: SHARED: efficacy and safety of sintilimab in combination with concurrent chemoradiotherapy (cCRT) in patients with locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma.
Presentation Type: Poster
Abstract Number: 4040
Researcher: Professor Baorui Liu, Professor Jia Wei, Nanjing Drum Tower Hospital, Jiangsu, China

Cancer Type: Endometrial Cancer
Topic: Anlotinib plus Sintilimab in patients with recurrent advanced endometrial cancer：A prospective open-label, single-arm, phase II clinical trial
Presentation Type: Poster
Abstract Number: 5583
Researcher: Professor Jundong Li, Sun Yat-Sen University Cancer Center, Guangdong, China

Cancer Type: Non-small-cell Lung Carcinoma
Topic: A Single-arm phase Ib study of autologous cytokine-induced killer (CIK) cell immunotherapy in combination with sintilimab plus chemotherapy in patients with advanced non-small-cell lung cancer(NSCLC)-CCICC-002
Presentation Type: Poster
Abstract Number: 2531
Researcher: Professor Xiubao Ren, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China

Cancer Type: NK/T Lymphoma
Topic: Combination of sintilimab, anlotinib and pegaspargase "Sandwich" with radiotherapy in localized natural killer/T cell Lymphoma: A multicenter, phase 2 study
Presentation Type: Poster
Abstract Number: 7537
Researcher: Professor Zhiming Li, Sun Yat-Sen University Cancer Center, Guangdong, China

Cancer Type: Hepatocellular Carcinoma
Topic: Sintilimab plus anlotinib as first-line therapy in patients(pts)with advanced hepatocellular carcinoma(aHCC)
Presentation Type: Abstract
Abstract Number: e16146
Researcher: Professor Xiaofeng Chen, Jiangsu Province Hospital, Jiangsu, China

Cancer Type: Gastric Cancer
Topic: CO-STAR: Surgical conversion feasibility trial of sintilimab (PD-1 inhibitor) combined with Nab-PTX, S-1 and apatinib for the first-line treatment of stage IV gastric cancer (GC)
Presentation Type: Abstract
Abstract Number: e16041
Researcher: Professor Han Liang, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China