On May 26, 2023 Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) ("Innate" or the "Company") reported that the abstract entitled "A first-in-human study of CD123 NK Cell Engager SAR443579 in relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia or high risk-myelodysplasia" was published on the ASCO (Free ASCO Whitepaper) 2023 Annual Meeting website (Press release, Innate Pharma, MAY 26, 2023, View Source [SID1234632143]). The abstract concludes that SAR’579, in development by Sanofi, was well tolerated up to doses of 3 mg/kg QW with observed clinical benefit in patients with relapsed/refractory acute myeloid leukaemia (R/R AML).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We are very pleased to see in this dose escalation Phase 1/2 update reported by Sanofi, the first clinical responses and good tolerability for SAR’579/IPH6101 targeting CD123 in relapsed/refractory acute myeloid leukaemia," said Mondher Mahjoubi, Chief Executive Officer of Innate Pharma. "Although the data are preliminary, the clinical data from SAR’579 are encouraging, and we look forward to the full presentation of this trial at the 2023 ASCO (Free ASCO Whitepaper) Annual Meeting, as well as further updates as other assets of our ANKET platform enter the clinic."

"The NK cell engager SAR’579, targeting CD123 is a remarkably designed investigational drug based on the ANKET platform and the result of a strong partnership between Sanofi and Innate scientists," adds Valeria Fantin, Global Head of Oncology Research at Sanofi.

"It is exciting to see these early clinical results at the 2023 ASCO (Free ASCO Whitepaper) meeting," said Peter. C. Adamson, MD, Global Head, Oncology Development at Sanofi. "We look forward to the continued development of SAR’579 and are thankful to the investigators leading the clinical effort and the patients/families who have volunteered to participate in this trial."

ASCO abstract presentation details:

SAR’579 / IPH6101

Abstract: 7005
Abstract Title: A first-in-human study of CD123 NK cell engager SAR443579 in relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, or high-risk myelodysplasia.
Session Type/Title: Oral Abstract Session – Hematologic Malignancies – Leukemia, Myelodysplastic Syndromes, and Allotransplant
Session Date and Time: 6/2/2023, 1:00 PM – 4:00 PM
Actual Presentation Time: 2:24 PM – 2:36 PM
About ANKET

ANKET (Antibody-based NK cell Engager Therapeutics) is Innate’s proprietary platform for developing next-generation, multi-specific natural killer (NK) cell engagers to treat certain types of cancer.

This versatile, fit-for-purpose technology is creating an entirely new class of molecules to induce synthetic immunity against cancer.