Infinity reported at the 55th Annual Meeting of the American Society for Hematology (ASH) (Free ASH Whitepaper) Phase 1 data of IPI-145 monotherapy in patients with relapsed or refractory indolent non-Hodgkin lymphoma (iNHL), demonstrating that IPI-145 was generally well tolerated and clinically active, with an overall response rate (ORR) of 73 percent, including three complete responses, among 15 patients receiving IPI-145 dosed at ≤ 25 mg twice daily (BID) (Press release Infinity Pharmaceuticals, FEB 25, 2014, View Source;p=RssLanding&cat=news&id=1903166 [SID:1234500160]). Data also showed that 53 percent of patients remained progression free for over one year. These data support the clinical rationale for DYNAMOTM, the ongoing Phase 2 study of IPI-145 in patients with refractory iNHL.

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