On November 2, 2023 IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta T cell therapies, reported an abstract detailing new, positive data from the Phase 1 investigator-sponsored trial of INB-100 in patients with hematologic malignancies has been selected for poster presentation at the 65th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition taking place December 9-12, 2023 (Press release, In8bio, NOV 2, 2023, View Source [SID1234636767]).
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Details for the ASH (Free ASH Whitepaper) 2023 presentation are as follows:
Title: INB-100: A Pilot Study of Donor Derived, Ex-Vivo Expanded/Activated Gamma-Delta T Cell (EAGD) Infusion Following Haploidentical Hematopoietic Stem Cell Transplantation and Post-Transplant Cyclophosphamide (PTCy)
Presenter: Joseph McGuirk, DO, The University of Kansas Cancer Center
Abstract #: 4853
Session Name: Cellular Immunotherapies: Early Phase and Investigational Therapies: Poster III
Date and Time: Monday, December 11, 2023, 6:00 PM – 8:00 PM PDT
Ten patients have been treated, completing the dose-escalation of this Phase 1 trial as of the abstract data cutoff of July 14, 2023. Updated data on safety and efficacy, including CRs and durability of response will be presented in December.
About the INB-100 Phase 1 Trial
The Phase 1 clinical trial (NCT03533816) is a dose-escalation trial of allogeneic derived, gamma-delta T cells from matched related donors that have been expanded and activated ex vivo and administered systemically to patients with hematologic malignancies following hematopoietic bone marrow transplantation (HSCT). The single-institution clinical trial is currently being conducted at The University of Kansas Cancer Center (KUCC). The primary endpoints of this trial are safety and tolerability, and secondary endpoints include rates of GvHD, relapse rate and overall survival.