On September 29, 2023 IN8bio, Inc. (Nasdaq: INAB), a leading clinical-stage biopharmaceutical company focused on innovative gamma-delta T cell therapies, reported two poster presentations reporting positive data at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 38th Annual Meeting, taking place November 1-5, 2023, in San Diego, CA (Press release, In8bio, SEP 29, 2023, View Source [SID1234635540]). The presentations will showcase biological correlative data from the ongoing Phase 1 clinical trial of INB-200, targeting newly diagnosed glioblastoma multiforme (GBM) and pre-clinical insights on IN8bio’s induced pluripotent stem cell (iPSC) gamma-delta T cell platform.
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Details of the presentations at SITC (Free SITC Whitepaper) 2023 are as follows:
Title: INB-200: Phase I study of gene modified autologous gamma-delta (γδ) T cells in newly diagnosed glioblastoma (GBM) patients receiving maintenance temozolomide (TMZ): immunobiologic correlative data
Abstract #: 637
Location: Exhibit Halls A and B1 – San Diego Convention Center
Data and Time: Friday November 3, 2023, 9:00 AM – 8:30 PM PDT
Title: The Development of "Off-the-Shelf" manufacturing strategies of iPSC-based Gamma-Delta T Cells
Abstract #: 418
Location: Exhibit Halls A and B1 – San Diego Convention Center
Data and Time: Saturday November 4, 2023, 9:00 AM – 8:30 PM PDT
About the INB-200 Phase 1 Trial
INB-200 is a genetically modified autologous drug resistant immunotherapy (DRI) product candidate for the treatment of solid tumors. This novel platform utilizes genetic engineering to generate chemotherapy resistant gamma delta T cells which can be administered concurrently with standard-of-care treatment in solid tumors. This is a powerful, synergistic treatment approach enabling gamma-delta T cells to persist in the presence of chemotherapy, and maintain their natural ability to recognize, engage and kill cancer cells.
INB-200 is the first genetically engineered gamma-delta T cell therapy to be administered to patients with solid tumors and our initial indication is in GBM.