On January 31, 2022 IDEAYA Biosciences, Inc. (NASDAQ: IDYA), a synthetic lethality focused precision medicine oncology company committed to the discovery and development of targeted therapeutics, reported that initiation of IND-enabling studies for IDE161, a potential first-in-class PARG inhibitor development candidate (Press release, Ideaya Biosciences, JAN 31, 2022, View Source [SID1234607534]). The company also exercised its option for an exclusive worldwide license from Cancer Research Technology Ltd., dba Cancer Research UK (CRUK), and University of Manchester.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
IDE161 is a potential first-in-class small molecule inhibitor of poly (ADP-ribose) glycohydrolase, or PARG, a novel target in the same clinically validated pathway as poly (ADP-ribose) polymerase, or PARP. IDEAYA plans to evaluate IDE161 in patients having tumors with homologous recombination deficiencies (HRD), including BRCA1 and BRCA2, and potentially other genetic alterations identified through IDEAYA’s biomarker discovery platform.
"We are very excited about potential development opportunities for IDE161. We have shown dose-dependent in vivo efficacy of PARG inhibitors as monotherapy with tumor regression or stasis in multiple CDX models and PDX models, including in ovarian cancer, gastric cancer and breast cancer models. Significantly, we have observed in vivo efficacy of PARG inhibitors in BRCA1 and BRCA2 models which are refractory to or have acquired resistance to PARP inhibitors, suggesting an opportunity for clinical differentiation," said Dr. Michael White, Senior Vice President and Chief Scientific Officer of IDEAYA.
"We identified IDE161 through our internal drug-discovery platform, and in parallel, we have invested significantly in translational biology and biomarker discovery. We believe PARG inhibitors could be substantially impactful for BRCA1 and BRCA2 patients non-responsive to PARP inhibitors. We are excited to advance IDE161 as a first-in-class development candidate toward the clinic," said Yujiro Hata, President and Chief Executive Officer of IDEAYA.
IDEAYA is targeting an IND submission for IDE161 in the fourth quarter of 2022, subject to satisfactory completion of ongoing preclinical and IND-enabling studies.
Following the option exercise with Cancer Research UK and University of Manchester, IDEAYA holds exclusive worldwide license rights covering a broad class of PARG inhibitors. IDEAYA owns or controls all commercial rights in IDE161, subject to certain economic obligations pursuant to its exclusive, worldwide license with Cancer Research UK and University of Manchester.