On June 4, 2021 Ichnos Sciences Inc., a global biotechnology company developing innovative biologics in oncology and autoimmune diseases, reported preclinical data that support the potential of ISB 1342, a first-in-class bispecific T-cell engager targeting CD38 expressed on the surface of multiple myeloma (MM) cells (Press release, Ichnos Sciences, JUN 4, 2021, View Source [SID1234583536]). ISB 1342 is currently in Phase 1 (NCT03309111) for the treatment of patients with MM that have relapsed or do not respond to available therapies. Ichnos shared the data via a prerecorded video presentation at the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting.

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Ichnos’ data demonstrate the ability of ISB 1342 to redirect T lymphocytes against tumor cells expressing varying levels of CD38 in preclinical in vitro and in vivo potency models. ISB 1342 engages a different epitope than do approved CD38-targeted biologics, and these models suggest that it may be effective in patients who have progressed despite treatment with such therapies.

"The data confirm the potential for ISB 1342 in patients with relapsed/refractory multiple myeloma," said M. Lamine Mbow, Ph.D., Head of the New Biologics Entity unit at Ichnos. "ISB 1342 demonstrates strong in vitro killing potency against tumor cell lines with different expression levels of CD38; the in vivo data show strong tumor-killing potential in a therapeutic model of disease."

ISB 1342 is based on Ichnos’ proprietary BEAT technology platform, which is the Bispecific Engagement by Antibodies based on the T-cell receptor. Using this platform, Ichnos is exploring the full design space for treating cancer and engineering bi-/tri-specific antibodies capable of simultaneously engaging tumor and immune cells.

The video presentation is available to registered attendees of ASCO (Free ASCO Whitepaper) starting today. Additional details are below:

Poster 8044
ISB 1342: A first-in-class CD38 T-cell engager for the treatment of relapsed/refractory multiple myeloma
Marie-Agnès Doucey, Ph.D., et al.abstract)