On March 28, 2024 Iambic Therapeutics reported it will highlight new preclinical data for IAM1363, a selective and brain-penetrant inhibitor of HER2 signaling for the treatment of HER2-driven cancers, in a poster presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 5-10 in San Diego (Press release, Iambic Therapeutics, MAR 28, 2024, View Source [SID1234641597]).

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The poster presentation will showcase preclinical data illustrating how the unique binding mechanism and potent HER2 activity of IAM1363 overcomes multiple resistance mechanisms and how its strong EGFR avoidance widens the safety margin. IAM1363 potently inhibits both the wild type and mutant forms of HER2, showing over 1000-fold selectivity against EGFR due to a unique binding mode and tumor enhancement not seen with other HER2 inhibitors, leading to exceptional in vivo efficacy and tolerability in various HER2-driven cancer models, including those resistant to existing HER2-targeting agents. IAM1363 is now in a Phase 1 clinical study.

Poster Presentation Details:

Presentation Title: Validation of a novel Type II HER2 inhibitor through preclinical studies across various cancer models

Abstract Number: 1980/29

Session Title: Kinase and Phosphatase Inhibitors 2

Location: Poster Section 25

Date and Time: Monday, April 8th; 9:00 – 12:30 PT

Presenter: Lana Kulyk, PhD