On June 12, 2020 I-Mab (the "Company") (Nasdaq: IMAB), a clinical stage biopharmaceutical company committed to the discovery, development and commercialization of novel biologics, reported that it will be presenting preclinical data on a newly developed, novel asset TJ-CD4B, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II on June 22-24, 2020 (Press release, I-Mab Biopharma, JUN 12, 2020, View Source [SID1234561071]).
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TJ-CD4B, also known as ABL111, is a Claudin 18.2 and 4-1BB bispecific antibody jointly developed with South Korea-based ABL Bio, Inc. (Kosdaq: 298380, hereafter "ABL"). TJ-CD4B is from I-Mab’s emerging bispecific antibody portfolio designed to create novel drug molecules that synergize two pathways for better clinical efficacy. By linking with an antibody against Claudin 18.2, a gastric- and pancreatic-specific cancer antigen, TJ-CD4B/ABL111 is uniquely structured to supercharge T cells in a Claudin 18.2-dependent manner, enhancing anti-tumor immunity while potentially minimizing toxicity.
The pre-clinical validation of TJ-CD4B/ABL111 to be presented at AACR (Free AACR Whitepaper) signifies the overall progress of I-Mab’s bispecific antibody portfolio, reflecting Company’s discovery and CMC capabilities to engineer novel molecules with combined target specificities. I-Mab plans to advance more novel bispecific antibodies towards clinical development stage, following the lead of TJ-CD4B/ABL111.
The poster presentation (Abstract #5644) is available for on-demand viewing starting 9:00 am EDT, 22 June, and will remain for viewing by registered attendees for at least three months after the virtual meeting.
The abstract is available online at:
View Source!/9045/sessions/5644/1