On July 25, 2024 Harbour BioMed (the "Company"; HKEX: 02142), a global biopharmaceutical company committed to the discovery, development, and commercialization of novel antibody therapeutics focusing on oncology and immunology, reportedc that the Company will release the latest clinical data on its first-in-class fully human anti-B7H7/HHLA2 monoclonal antibody, HBM1020, for advanced solid tumors at the ESMO (Free ESMO Whitepaper) Congress 2024, taking place from September 13-17, 2024, in Barcelona, Spain (Press release, Harbour BioMed, JUL 25, 2024, View Source [SID1234645095]).
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HBM1020, generated from Harbour Mice H2L2 transgenic mice platform, is the first therapeutic monoclonal antibody against B7H7/HHLA2 to have entered clinical development globally. Data from the dose-escalation study of a phase I, multi-center, open-label trial (NCT05824663) demonstrated the promising safety and tolerability profiles of HBM1020 in patients with advanced solid tumors.
The findings will be displayed as a poster presentation during the ESMO (Free ESMO Whitepaper) Congress 2024. Details of the presentation are as follows:
Title: Ph I Dose-Escalation Study of HBM1020, a Novel Anti-B7H7 Antibody in Patients with Advanced Solid Tumors
Presentation Number: 1010P
Onsite Poster Display Date: Saturday, September 14, 2024
Speaker: Jason Henry
All accepted abstracts will be published online on the ESMO (Free ESMO Whitepaper) website.
About HBM1020
HBM1020 is a first-in-class fully human monoclonal antibody generated from Harbour Mice H2L2 transgenic mice platform, targeting B7H7/HHLA2.
B7H7, also known as HHLA2, is a novel immune modulatory molecule belonging to the B7 family. The B7 family is of central importance in regulating the T-cell response, making these pathways very attractive in cancer immunotherapy. Most of the validated targets in immune-oncology so far are related to B7 family, including PD-(L)1, and CTLA-4. The therapies against B7 family targets have already shifted the paradigm for cancer therapy with outstanding clinical benefits. As a newly discovered member of the B7 family, B7H7 expression is found non-overlapping with PD-L1 expression in multiple tumor types, which indicates an alternative immune evasion pathway besides PD-(L)1. In PD-L1 negative/ refractory patients, B7H7 potentially plays a critical role for tumor cells to escape immune surveillance. HBM1020 can enhance anti-tumor immunity by blocking the novel immune checkpoint target. Preclinical data demonstrated its immune activation and anti-tumor functional activities.
With its innovative biology mechanisms, HBM1020 presents a novel anti-tumor therapeutics complementary to PD-(L)1 therapeutics to patients, especially for PD-L1 negative/refractory patients.