On October 7, 2014 Halozyme Therapeutics reported the issuance of U.S. Patent No. 8,846,034 claiming methods for selecting a subject for treatment of a hyaluronan-associated disease with an anti-hyaluronan agent, such as PEGPH20, as well as diagnostic agents for the detection and quantification of hyaluronan in a biological sample in patients (Press release Halozyme, OCT 7, 2014, View Source [SID:1234500800]). Combinations and kits for use in practicing the methods are also provided. PEGPH20 is an investigational PEGylated form of rHuPH20 under development by Halozyme, which degrades the hyaluronan coating that may provide a supportive environment in many solid tumors.

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"We are pleased to receive recognition for these biotechnology innovations," commented Dr. Helen Torley, President and CEO. "This companion diagnostic will provide important data for identifying and evaluating those patients and tumors that can benefit most from PEGPH20 therapy."

The issued U.S. patent is anticipated to expire on October 28, 2032, which includes the patent term adjustment. To date, similar claims are pending in eleven countries, as well as the Eurasian and European regions. Additional information about these patents may be found on the U.S. Patent and Trademark Office and on the European Patent Office Web sites.