On May 31, 2023 Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, reported that the company and its research collaborators will present data from 17 studies that highlight the contribution of Guardant blood tests and real-world data to advances in precision oncology and cancer screening at the 2023 American Society for Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, June 2-6 in Chicago (Press release, Guardant Health, MAY 31, 2023, View Source [SID1234632313]).

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Data being presented from multiple studies demonstrate the utility of Guardant Health’s portfolio of cancer tests to help healthcare professionals optimize care for patients at all stages of the disease—from detecting early-stage cancers to identifying the presence of residual disease and delivering insights that inform treatment to improve outcomes.

"We look forward to sharing new data at ASCO (Free ASCO Whitepaper) that demonstrate scientific and clinical advances across the entire continuum of cancer care," said Helmy Eltoukhy, Guardant Health chairman and co-CEO. "In particular, research demonstrating the tremendous potential of epigenomic analysis through our new Guardant Infinity platform shows how gaining deeper insights into the tumor microenvironment can help us identify new potential biomarker targets for therapy and predictive markers for treatment resistance."

Featured presentations include:

Guardant Health will present a session highlighting the performance of the Guardant Infinity platform in the detection of homologous recombination deficiency (HRD) status in patients with breast cancer. With HRD prediction, the platform provides a comprehensive, minimally invasive solution for PARPi and DNA damage treatment selection and longitudinal monitoring, and an exploratory platform for investigating epigenetic signals that may underpin resistance. (Abstract 556, Sunday, June 4, 8-11am, Hall A)
Guardant Health collaborators will present a session on the ESR1 mutational landscape and the impact of co-existing resistance variants on clinical outcomes in patients with metastatic breast cancer. The study demonstrates that plasma-based genotyping can detect ESR1 mutations that qualify patients to receive FDA-approved SERD therapy, including repeat testing over time even when an ESR1 mutation was not present in a past sample. The study also explores additional co-mutations ascertained through broad genomic liquid profiling and their impact on patient survival. (Abstract 1074, Sunday, June 4, 8-11am, Hall A)
Guardant Health collaborators will present results from HERALD/EPOC1806, a multicenter, investigator-initiated phase 2 trial of T-DXd for patients with HER2 (ERBB2)-amplified advanced solid tumors identified in cfDNA by Guardant360 (G360) as a part of the Nationwide Cancer Genome Screening Project (GOZILA study) in Japan. Results indicate that T-DXd achieved a high objective response rate and durable response with a manageable safety profile in patients with advanced solid tumors and HER2 amplification detected in cfDNA. (Abstract 3014, Saturday, June 3, 1:15–2:45pm, Grand Ballroom S100bc)
Complete list of Guardant Health and collaborator presentations at ASCO (Free ASCO Whitepaper)

Abstract

Poster

Title (Hall A unless otherwise noted)

Product

Saturday, June 3 | 8:00 am – 11:00 am

3030

228

Changes in ctDNA levels as an early indicator of outcomes in advanced NSCLC treated with TKI: Initial findings from a retrospective aggregate analysis of 8 clinical trials

Guardant360

3053

251

cfDNA NGS detection of fusions acquired as mechanisms of resistance in the post-EGFR setting across multiple solid tumors

Guardant360

3102

300

Efficacy and safety of futibatinib for refractory advanced solid malignancies with FGFR alterations identified in circulating tumor DNA: TiFFANY, A GOZILA-affiliated Trial

Guardant360

2561

403

Clinical outcomes of immune checkpoint inhibitor treatment in patients with classic cold tumors identified to have a high tumor mutational burden via ctDNA

Guardant360

3049

247

ctDNA-based genomic landscape analysis to evaluate molecular brake and gatekeeper mutations in FGFR2 alterations

GuardantINFORM

Saturday, June 3 | 1:15 pm – 4:15 pm

3014

212

Tissue-agnostic efficacy of trastuzumab deruxtecan (T-DXd) in advanced solid tumors with HER2 amplification identified by plasma cell-free DNA (cfDNA) testing: Results from a phase 2 basket trial (HERALD/EPOC1806) (Note: Location is Grand Ballroom S100bc)

Guardant360

TPS6654

145b

Understanding patient acceptance and compliance of a blood-based colorectal cancer screening test

Shield

Sunday, June 4 | 8:00 am – 11:00 am

556

386

Detection of homologous recombination deficiency (HRD) using a novel genomic and epigenomic liquid biopsy assay in patients with breast cancer

Guardant Infinity

9133

121

Investigating racial inequities of circulating tumor DNA (ctDNA) use in patients with non-small cell lung cancer: A real world analysis

Guardant360

1074

295

ESR1 mutational landscape and impact of co-existing resistance variants on clinical outcomes in patients with metastatic breast cancer

Guardant360

1081

302

Real-world outcomes of patients with advanced breast cancer with and without resistance alterations detected in cell-free circulating tumor DNA prior to CDK4/6 inhibitor plus endocrine therapy treatment

GuardantINFORM

9029

17

Impact of EML4-ALK fusion variant and co-occurring TP53 mutation on treatment duration of first-line next-generation ALK TKIs in ALK fusion+ NSCLC

GuardantINFORM

Monday, June 5 | 8:00 am – 11:00 am

3540

240

Does serial circulating tumor DNA (ctDNA) monitoring identify additional acquired actionable alterations in metastatic colorectal cancer (mCRC)?

Guardant360

TPS3625

324b

Phase II/III study of circulating tumor DNA as a predictive biomarker in adjuvant chemotherapy in patients with stage II colon cancer: NRG-GI005 (COBRA)

Guardant Reveal

3567

267

Reversion of RAS mutations in metastatic colorectal cancer in the CCTG CO.26 clinical trial

GuardantOMNI

TPS3626

325a

The Ohio State University Guardant Shield Colorectal Cancer Screening Project

Shield

Monday, June 5 | 1:15 pm – 4:15 pm

TPS1610

203a

Screening for high frequency malignant disease (SHIELD)

Shield (Next Generation)

The full abstracts for Guardant Health and a list of all abstracts being presented at the meeting can be found at the ASCO (Free ASCO Whitepaper) website here.

For more information and updates from the meeting, follow Guardant Health on LinkedIn and Twitter or visit ASCO (Free ASCO Whitepaper) booth #19119.