On December 3, 2019 Genomic Testing Cooperative, LCA (GTC) reported that they will be presenting data on their proprietary AI-based algorithms and RNA and DNA testing at the American Association of Hematology (ASH) (Free ASH Whitepaper) annual meeting (Press release, Genomic Testing Cooperative, DEC 3, 2019, View Source [SID1234553223]). In collaboration with multiple academic centers, GTC developed new approaches for the classification of diseases and prediction of response to combination therapy.

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Dr. Maher Albitar, GTC Chief Executive Officer and Chief Medical Officer, stated "Cancer is complex disease and requires complex biomarkers for predicting its behavior. RNA Sequencing provides a wealth of information that can be used for predicting clinical course and response to combination therapy. RNA sequencing data, when combined with mathematical algorithms, can provide reliable means to manage and treat cancer. GTC is committed to be the leader in innovation in developing molecular biomarkers to help physicians select the proper combination therapy for their patients."

Highlights of GTC presentations include:
-Targeted next generation sequencing (NGS) of RNA is reliable and practical for routine clinical testing.

-RNA sequencing data when used with AI or Bayesian statistics can provide powerful means for predicting clinical behavior and response to combination therapy

-Testing for mutations using RNA may provide a new paradigm for better characterizing and monitoring of cancers

-Liquid biopsy provides important clinical information in patients with acute myeloid leukemia.

The following is a list of studies that will be presented by GTC and its collaborators at ASH (Free ASH Whitepaper):
1) 2891-Title: "Cell of Origin Classification of DLBCL Using Targeted NGS Expression Profiling and Deep Learning"

Collaborators: University of Texas MD Anderson Cancer Center, Houston, TX; University of California, Irvine, CA; University Hospital Basel, Basel, Switzerland; University of Verona, Verona, Italy; Columbia University Medical Center, New York, NY; Aalborg University Hospital, Aalborg, Denmark; Well Cornell Medical College, New York, NY; Cleveland Clinic, Cleveland, OH; San Raffaele Scientific Institute, Milano, Italy; San Raffaele Hospital, Milan, Italy; Odense University Hospital, Odense, Denmark; Instituto de Investigación Marqués De Valdecilla, Santander, Spain; University Hospital Nijmegen, Nijmegen, NLD; Houston Methodist Hospital, Houston, TX; Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

2) 2730-Title: "Higher Stability of Mutant IDH1/2 mRNA As Compared to Wild-Type mRNA in Patients with Acute Myeloid Leukemia"

Collaborators: Departments of Leukemia, Stem Cell Transplantation, and Hematopathology, UT MD Anderson Cancer Center, Houston, TX

3) 1314-Title: "Expression Profiling of mRNA By Next Generation Sequencing and the Development of Algorithm for Predicting Response in Acute Myeloid Leukemia"

Collaborators: Department of Computer Science, Georgia Southern University, Savannah, Georgia;
Departments of Leukemia, Stem Cell Transplantation, and Hematopathology, UT MD Anderson Cancer Center, Houston, TX

4) 1499-Title: Higher Stability of Mutant mRNA As Compared to Wild-Type mRNA in Diffuse Large B-Cell Lymphoma

Collaborators: University of Texas MD Anderson Cancer Center, Houston, TX; University of California, Irvine, CA; University Hospital Basel, Basel, Switzerland; University of Verona, Verona, Italy; Columbia University Medical Center, New York, NY; Aalborg University Hospital, Aalborg, Denmark; Well Cornell Medical College, New York, NY; Cleveland Clinic, Cleveland, OH; San Raffaele Scientific Institute, Milano, Italy; San Raffaele Hospital, Milan, Italy; Odense University Hospital, Odense, Denmark; Instituto de Investigación Marqués De Valdecilla, Santander, Spain; University Hospital Nijmegen, Nijmegen, NLD; Houston Methodist Hospital, Houston, TX; Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

5) 2592-Title: Sequencing of Circulating Cell-Free DNA in Patients with AML Detects Clinically Significant Mutations Not Detected in Bone Marrow: The Role for Complementary Peripheral Blood and Bone Marrow Genomic Analysis

Collaborators: Departments of Leukemia, Genomic, and Hematopathology, UT MD Anderson Cancer Center, Houston, TX.