On July 28, 2020 Clarity Pharmaceuticals, a radiopharmaceutical company focused on the treatment of serious disease,reported that the first patient has been treated in the C-BOBCAT study (Copper-64 BOmbesin in Breast CAncer Trial) (Press release, Clarity Pharmaceuticals, JUL 28, 2020, View Source [SID1234562447]).
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The C-BOBCAT trial is a first-in-human, investigator-led clinical trial investigating 64Cu-SAR-Bombesin (SAR-BBN) in patients with hormone receptor positive/HER2 negative (HR+/HER2-) metastatic breast cancer. The trial is led in collaboration with Associate Professor Louise Emmett, Director of Theranostics and Nuclear Medicine, at St Vincent’s Hospital in Sydney.
Bombesin is a natural homolog to the mammalian gastrin-releasing peptide, which is able to specifically bind to the gastrin-releasing peptide receptor (GRPr). GRPr is present on the membrane of most prostate, breast, ovarian and small cell lung cancers, gastrointestinal stromal tumours, and in tumoural vessels of urinary cancers. In relation to breast cancer, HR+/HER2- breast cancers make up roughly 67%1 of new breast cancer cases diagnosed each year, affecting roughly 181,000 women in 2019 in the USA2 alone, and approximately 13,000 women in Australia3.
Clarity’s Executive Chairman, Dr Alan Taylor, said, "We are excited to commence this trial as SAR-BBN is Clarity’s second product after SARTATE to enter the clinical development stage. We are looking forward to progressing this study with our collaborators at St Vincent’s Hospital in Sydney, who have been involved in some pioneering radiopharmaceutical studies in recent times. We hope that SAR-BBN will allow for Positron Emission Tomography (PET) imaging and localisation of metastatic breast cancer lesions that express GRPr, and we look forward to utilising that data to progress SAR-BBN into other diagnostic and therapeutic trials in a range of cancers that express GRPr with our ultimate goal of better treating children and adults with cancer."
References
American Cancer Society, Surveillance Research (2017)
National Cancer Institute, Cancer Stat Facts: Female Breast Cancer, View Source
Australian Government Cancer Statistics, Breast cancer in Australia statistics, View Source