On October 31, 2022 Imugene Limited (ASX: IMU), a clinical stage immuno-oncology company, reported that its Phase 1 MAST (metastatic advanced solid tumours) study evaluating the safety of novel cancer-killing virus CF33-hNIS (VAXINIA) has advanced with the first patient dosed within intratumoral (IT) cohort 2 of the trial (Press release, Imugene, OCT 31, 2022, View Source [SID1234622596]).

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This follows the announcement in September that the first patient had been dosed as part of the intravenous (IV) cohort 1 of the study.

A multicenter Phase 1 trial, the VAXINIA Phase 1 MAST study has to date delivered a low dose to patients with metastatic or advanced solid tumours who have had at least two prior lines of standard of care treatment. The City of Hope-developed oncolytic virus has been shown to shrink colon, lung, breast, ovarian and pancreatic cancer tumours in preclinical laboratory and animal models¹.

The clinical trial is titled "A Phase I, Dose Escalation Safety and Tolerability Study of VAXINIA (CF33-hNIS), Administered Intratumorally or Intravenously as a Monotherapy or in Combination with Pembrolizumab in Adult Patients with Metastatic or Advanced Solid Tumours (MAST)." The trial is anticipated to run for approximately 24 months and is funded from existing budgets and resources.

Imugene MD & CEO, Ms Leslie Chong said: "The VAXINIA trial continues to progress on schedule and we’re very excited to see the results it can deliver for these patients dealing with significant tumour growth."