On February 27, 2014 Epizyme reported the achievement of the lead candidate selection milestone for one of the histone methyltransferase (HMT) targets in the company’s collaboration with GSK (Press release Epizyme, FEB 27, 2014, View Source [SID:1234500178]). This achievement triggers a milestone payment of $2 million and follows the announcement in January 2014 of the achievement of a development candidate milestone for another of the HMT targets in the collaboration, which earned Epizyme a $4 million milestone payment.