Duke Street Bio Announces First Patient Dosed in Phase I Trial with DSB2455, a Next Generation PARP1 Selective Inhibitor for the Treatment of Solid Tumours

On December 2, 2024 Duke Street Bio Ltd, a precision medicine biotech developing next generation small molecule cancer therapies, reported that the first patient has been dosed in a Phase I trial evaluating the highly selective PARP1 inhibitor, DSB2455, in patients with solid tumours. DSB2455 is a potentially best-in-class, potent CNS penetrant PARP1 inhibitor with profound selectivity over the closely related enzyme PARP2 (Press release, Duke Street Bio, DEC 2, 2024, View Source [SID1234648716]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The Phase Ia/Ib trial is a multi-centre adaptively designed dose escalation study with expansion cohorts to assess the safety, tolerability, and activity of DSB2455 as monotherapy or in combination with anti-cancer agents in participants with advanced malignancies. First-generation non-selective PARP1/2 inhibitors have provided significant therapeutic benefit to patients whose tumours exhibit homologous repair (HR) deficiencies including BRCA mutations. However, their use has been associated with haematological toxicities that have restricted their application, particularly in combination with standard-of-care chemotherapy.

"Given that PARP2 is considered to drive haematoxicity, we believe that DSB2455 exhibits the optimal potency and selectivity profile to enhance efficacy and safety and may offer the potential to enable combination approaches with chemotherapy and radiotherapy" said Dónal Landers, M.D., Ph.D., Chief Medical Officer at Duke Street Bio Ltd.