On April 1, 2025 Domain Therapeutics ("Domain" or "the Company"), the GPCR experts harnessing deep receptor biology to develop breakthrough treatments for patients, reported that it will be presenting new preclinical and clinical data on its key oncology programs – DT-7012, and DT-9081, alongside preclinical findings on its PAR2 biased negative allosteric modulator ( NAM ) program – at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) ( AACR (Free AACR Whitepaper) ) Annual Meeting 2025, taking place in Chicago, US from 25-30 April 2025 (Press release, Domain Therapeutics, APR 1, 2025, View Source [SID1234651715]).

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The poster presentations will highlight Domain’s progress in leveraging GPCR-targeting therapies to modulate the tumor microenvironment and enhance anti-cancer immune responses.

Details of the poster presentations are as follows:

Poster Title: Comprehensive Characterization of DT-7012, a Differentiated CCR8-Depleting Antibody for the Treatment of Solid Tumors
Session Category: Experimental and Molecular Therapeutics
Session Title: Antireceptors and Other Biological Therapeutic Agents
Date and Time: Sunday 27th April 2025, 14:00 – 17:00 CDT
Location: Poster Section 15
Poster Board Number: 4
Abstract Number: 7080

DT-7012 – A Differentiated CCR8-Depleting Antibody for Solid Tumors

DT-7012 is a highly selective, fully humanized monoclonal antibody targeting CCR8, a receptor predominantly expressed on tumor-resident regulatory T cells ( Tregs ), which suppress anti-tumor immunity.
The study characterizes DT-7012’s binding properties, effector functions, and Treg-depleting activity, supporting its transition into clinical development.

Poster Title: Clinical PK, PD and safety analysis of a phase I clinical trial of DT-9081, an EP4R-antagonist, for RP2D determination in patients with advanced solid tumors
Session Category: Clinical Research
Session Title: Modifiers of the Tumor Microenvironment
Date and Time: Monday 28th April 2025, 14:00 – 17:00 CDT
Location: Poster Section 30
Poster Board Number: 8
Abstract Number: 7450

DT-9081 – Phase I Clinical Data of an EP4R Antagonist for Advanced Solid Tumors

DT-9081 is an oral EP4 receptor ( EP4R ) antagonist designed to inhibit growth by blocking prostaglandin E2 ( PGE2 )-mediated immune suppression. Interim Phase I results demonstrate DT-9081’s favorable safety profile, linear pharmacokinetics, and dose-dependent inhibition of EP4R signaling, with data supporting the recommended Phase II dose ( RP2D ).

Poster Title: PAR2 inhibitors reduce resistance to immunotherapy against cancer
Session Category: Immunology
Session Title: Interplay between Immune System and Radio-, Chemo- and Targeted Therapies 2
Date and Time: Tuesday 29th April, 14:00 – 17:00 CDT
Location: Poster Section 40
Poster Board Number: 9
Abstract Number: 6606

PAR2 – Pivotal driver of resistance to immune checkpoint blockade ( ICB ) and T cell dysfunction in cancer

PAR2 biased NAM represents a transformative breakthrough in immuno-oncology, targeting tumor resistance to ICB. Preclinical findings demonstrate the unique mode of action of PAR2 inhibition. By reshaping the tumor microenvironment, it reduces immunosuppressive macrophages and increases antigen presentation, fostering robust anti-tumor immune responses and thereby improving patient outcomes.

Stephan Schann, Chief Scientific Officer of Domain Therapeutics, said: "These promising preclinical and clinical results for DT-7012 and DT-9081, alongside the preclinical findings on our PAR2 biased NAM demonstrate Domain’s unmatched knowledge in leveraging deep receptor biology to develop differentiated oncology treatments. We look forward to sharing these promising insights with the scientific community as we continue to push the boundaries to ultimately deliver better treatments and transform patients’ lives."

Abstracts are available in an online itinerary planner found here and will be available in an online only supplement to the AACR (Free AACR Whitepaper) journal Cancer Research one month after the conference.