On September 29, 2015 DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical company focused on the development and commercialization of new cancer therapies, reported that it will present an abstract entitled, "Dianhydrogalactitol (VAL-083) Offers Potential Therapeutic Alternatives in the Treatment of Pediatric Brain Tumors," at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Advances in Pediatric Research: From Mechanisms and Models to Treatment and Survivorship conference being held November 9–12, 2015 in Fort Lauderdale, FL (Press release, DelMar Pharmaceuticals, SEP 29, 2015, View Source [SID:1234507607]).
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The Company will present on Tuesday, November 10th during Poster Session A scheduled to begin at 4:30 p.m. The poster presentation will summarize the potential of VAL-083 as a new treatment for malignant pediatric brain tumors in the context of historical clinical trials sponsored by the U.S. National Cancer Institute and DelMar’s recent research.
The Company recently presented an update from its ongoing multicenter Phase I/II clinical study for the treatment of adult refractory glioblastoma multiforme (GBM) at the GBM2015 Conference. VAL-083 demonstrated a favorable safety-profile and doses up to 40mg/m2 were well tolerated by patients receiving three daily doses in a 21 day cycle. A sub-group analysis of patients receiving up to 5 mg/m2 daily x 3 every 21 days (low dose) versus those patients receiving 30mg/m2 or 40mg/m2 (high dose) of VAL-083 demonstrated a dose-related survival benefit in adult GBM patients failing standard front-line therapy and bevacizumab.
About VAL-083
VAL-083 is a "first-in-class," small-molecule chemotherapeutic. In more than 40 Phase I and II clinical studies sponsored by the U.S. National Cancer Institute, VAL-083 demonstrated safety and efficacy in treating a number of cancers including lung, brain, cervical, ovarian tumors and leukemia. VAL-083 is approved in China for the treatment of chronic myelogenous leukemia (CML) and lung cancer and has received orphan drug designation in Europe and the U.S. for the treatment of gliomas.
DelMar is currently studying VAL-083 in a multi-center Phase I/II clinical trial for patients with refractory GBM in accordance with the protocol that has been filed with the U.S. Food and Drug Administration (FDA) at five clinical centers in the United States: Mayo Clinic (Rochester, MN); UCSF (San Francisco, CA) and three centers associated with the Sarah Cannon Cancer Research Institute (Nashville, TN, Sarasota, FL and Denver, CO). As a potential treatment for glioblastoma, VAL-083’s mechanism of action appears to be unaffected by the expression of MGMT, a DNA repair enzyme that is implicated in chemotherapy resistance and poor outcomes following front-line treatment with Temodar (temozolomide).