On June 10, 2015 DelMar Pharmaceuticals reported that it will be presenting at the BIO International Convention being held June 15-18, 2015, in Philadelphia, PA (Press release, DelMar Pharmaceuticals, JUN 10, 2015, View Source [SID:1234505389]).
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Jeffrey Bacha, DelMar’s president and CEO, will present on Wednesday, June 17, 2015, at 10:15 a.m. EDT, in Theater 4 of the Pennsylvania Convention Center. Mr. Bacha will provide an update on the Company’s drug development programs with its lead product candidate VAL-083 (dianhydrogalactitol), including DelMar’s ongoing Phase 1/2 trial in refractory glioblastoma multiforme (GBM), the most common and deadly form of brain cancer, and upcoming clinical development plans in non-small cell lung cancer (NSCLC).
About the BIO International Convention
The BIO International Convention is considered one of the world’s largest, most influential biotech meetings and regularly attracts 15,000 of the most powerful biotech and pharma players from 65 countries, offering powerful business partnering, networking and education that go far beyond professional development. DelMar management will be available during the conference for meetings with potential drug development and commercialization partners from the biopharmaceutical industry. For more information, please visit View Source
About VAL-083
VAL-083 is a "first-in-class", small-molecule chemotherapeutic. In more than 40 Phase 1 and 2 clinical studies sponsored by the U.S. National Cancer Institutes, VAL-083 demonstrated safety and efficacy in treating a number of cancers including lung, brain, cervical, ovarian tumors and leukemia. VAL-083 is approved in China for the treatment of chronic myelogenous leukemia and lung cancer and has received orphan drug designation in Europe and the U.S. for the treatment of gliomas.
As a potential treatment for glioblastoma, VAL-083’s mechanism of action appears to be unaffected by the expression of MGMT, a DNA repair enzyme that causes chemotherapy resistance to front-line treatment with Temodar (temozolomide).
DelMar is currently studying VAL-083 in a multi-center Phase I/II clinical trial for patients with refractory glioblastoma multiforme (GBM) in accordance with the protocol that has been filed with the U.S. Food and Drug Administration (FDA). Eligible GBM patients must have failed both Avastin (bevacizumab) and Temodar (temozolomide) unless either of these therapies was contraindicated. (ClinicalTrials.gov Identifier NCT01478178).
The four current sites for the VAL-083 clinical trial include: The University of California, San Francisco (UCSF); The Mayo Clinic, Rochester MN; The Sarah Cannon Cancer Research Institute (SCRI), Nashville TN; and the SCRI affiliate site at Florida Cancer Specialists in Sarasota FL. DelMar anticipates opening additional clinical sites as the trial progresses. Further information on this clinical trial can be found on the company’s website at www.delmarpharma.com.