On May 3, 2024 Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, reported that new data supporting the utility of its DecisionDx-SCC test in patients with high-risk cutaneous squamous cell carcinoma (SCC) tumors located on the head and neck (H&N) will be shared at the 56th American College of Mohs Surgery (ACMS) Annual Meeting, being held May 2-5 in Phoenix (Press release, Castle Biosciences, MAY 3, 2024, View Source [SID1234642641]).

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"Mohs surgery is commonly used to remove high-risk SCC tumors located on a patient’s head or neck and is the best method to ensure complete removal of the tumor," said Sherrif Ibrahim, M.D., Ph.D., lead study author and board-certified Mohs micrographic surgeon and dermatologist at Rochester Dermatologic Surgery in Victor, New York. "In most cases, once a tumor is removed completely, the patient is in the clear. However, aggressive SCC tumors may still return in the same location from which they were removed or worse, spread to other parts of the body, posing a very serious health risk to patients.

"The data being presented at ACMS show the power of DecisionDx-SCC to identify these high-risk patients, enabling more risk-appropriate surveillance or adjuvant treatments to help reduce the patient’s risk of these events occurring."

Details regarding Castle’s poster at ACMS are included below:

Title: Addition of the 40-gene expression profile (40-GEP) test in risk assessment improves prognostic accuracy and risk stratification for high-risk cutaneous squamous cell carcinoma (HR-cSCC) of the head and neck successfully treated with Mohs micrographic surgery (MMS)
Poster Number: Poster 21
First and Presenting Author: Sherrif Ibrahim, M.D., Ph.D.
Location: Valley of the Sun Ballroom foyer (2nd floor), Sheraton Phoenix Downtown
Summary: Despite reported definitive, clear tumor margins, 5-8% of patients with high-risk SCC treated with Mohs surgery will still develop metastasis. This study included 417 patients who received definitive Mohs surgery to remove high-risk SCC tumors of the H&N with reported clear margins. DecisionDx-SCC testing of the tumor tissue before removal significantly increased the prediction accuracy of metastatic events, when used alone and when combined with National Comprehensive Cancer Network (NCCN) guidelines, Brigham and Women’s Hospital (BWH) staging or American Joint Committee on Cancer Staging Manual, 8th Edition (AJCC8) staging, to better guide risk-aligned patient care decisions regarding metastatic surveillance or the use of adjuvant treatments like radiation.
Presenting authors will be available to answer questions regarding their posters on Saturday, May 4, from 12-1 p.m. Mountain Standard Time. Abstracts will also be in ACMS’ CME & Abstract Book and available for online viewing via the Planstone abstract site.

About DecisionDx-SCC

DecisionDx-SCC is a 40-gene expression profile test that uses an individual patient’s tumor biology to predict individual risk of cutaneous squamous cell carcinoma metastasis for patients with one or more risk factors. The test result, in which patients are stratified into a Class 1 (low), Class 2A (higher) or Class 2B (highest) risk category, predicts individual metastatic risk to inform risk-appropriate management. Peer-reviewed publications have demonstrated that DecisionDx-SCC is an independent predictor of metastatic risk and that integrating DecisionDx-SCC with current prognostic methods can add positive predictive value to clinician decisions regarding staging and management.