On October 3, 2022 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported the 1st Symposium on IRAK4 in Cancer taking place virtually on October 7, 9:00am-1:00pm ET (Press release, Curis, OCT 3, 2022, View Source [SID1234621624]).

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Hosted by Drs. Guillermo Garcia-Manero, Hagop Kantarjian, and Amit Verma, this symposium will focus on IRAK4, an essential protein in innate immune response and promising target in the treatment of hematologic malignancies and other cancers. Experts across academia and industry will discuss IRAK4 biology, the present understanding of IRAK4 function, and the future of anti-cancer therapeutic development focused on this target.

"Following the success of the VISTA Symposium over the past two years, Curis is proud to be sponsoring the first symposium on IRAK4 in cancer," said James Dentzer, President, and Chief Executive Officer of Curis. "IRAK4 shows great promise as a potential immunotherapy target for the treatment of hematologic cancers, as well as solid tumors, and we look forward to advancing the conversation on how this promise is being translated into meaningful results for patients."

Symposium hosts:

Guillermo Garcia-Manero, M.D. – Symposium Co-Chair – Professor, Department of Leukemia; Chief, Section of Myelodysplastic Syndromes and Deputy Chair, Translational Research, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
Hagop Kantarjian, M.D. – Symposium Co-Chair – Professor, Department Chair, and Samsung Distinguished University Chair in Cancer Medicine, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center; Associate Vice President for Global Academic Programs, MD Anderson Cancer Center
Amit Verma, M.B.B.S. – Symposium Co-Chair – Professor, Department of Oncology (Medical Oncology), Department of Medicine (Oncology & Hematology), and Department of Developmental & Molecular Biology, Albert Einstein College of Medicine; Director, Division of Hemato-Oncology, Montefiore Department of Oncology; Associate Director, Translational Science, Montefiore Einstein Cancer Center; Co-Director, Montefiore Einstein Blood Cancer Institute.
Joining our hosts will be the following speakers and participants:

Omar Abdel-Wahab, M.D. – Edward P. Evans Chair in MDS, Director, Memorial Sloan Kettering Cancer Center (MSK) for Hematologic Malignancies; Member, Human Oncology and Pathogenesis Program & Leukemia Service
Kian-Huat Lim, M.D., Ph.D. – Associate Professor, Division of Oncology, Department of Medicine, Washington University School of Medicine in St. Louis
Alan List, M.D. – Chief Medical Officer, Precision BioSciences
Robert Martell, M.D., Ph.D. – Head of Research and Development, Curis
Dr. Grzegorz Nowakowski, M.D., Professor of Oncology and Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota, and Deputy Director, Clinical Research, Mayo Clinic Comprehensive Cancer Center
Marc Raaijmakers, M.D., Ph.D. – Professor of Hematology, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands
Daniel Starczynowski, Ph.D. – Katherine Stewart Waters Endowed Chair of Hematologic Malignancies; Co-Leader, Hematologic Malignancies Program; Co-Chief Scientific Officer, Innovation Ventures; Associate Director for Basic Sciences, UC Cancer Center; Professor, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
Ulrich Steidl, M.D., Ph.D. – Professor, Department of Cell Biology, Department of Oncology, and Department of Medicine (Oncology & Hematology), Albert Einstein College of Medicine; Deputy Director, and Associate Director for Basic Science, Montefiore Einstein Cancer Center; Co-Director, Montefiore Einstein Blood Cancer Institute; Interim Director, Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine
The virtual event will address topics including:

IRAK4 Biology
Biology Overview – Amit Verma, M.B.B.S
Spliceosomes – Daniel Starczynowski, Ph.D.
IL1RAP as a common upstream mechanism of IRAK4 activation – Ulrich Steidl, M.D., Ph.D.
Role of IRAK4 in Innate Immunity
Myddosome signaling and the inflammasome – Alan List, M.D.
Inflammatory signaling and dysregulation & hematopoietic recovery- Marc Raaijmakers, M.D., Ph.D.
IRAK4 in Hematologic Cancers
Myelodysplastic Syndrome and Acute Myeloid Leukemia – Guillermo Garcia-Manero
B cell malignancies – Grzegorz Nowakowski, M.D.
Dissecting the Mechanism of Action – Omar Abdel-Wahab, M.D.
IRAK4 in Solid Tumors
Pancreatic cancer & biliary, colorectal and gastric cancers – Kian-Huat Lim, M.D., Ph.D.
Industry Panel: IRAK4 Therapeutic Strategies
IRAK4’s Role in Therapy Resistance – Daniel Starczynowski
IRAK4 Kinase Inhibitor – Robert Martell, M.D., Ph.D.