On November 5, 2024 Compugen Ltd. (Nasdaq: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, reported that data supporting the anti-tumor activity and safety profile of the triple combination COM701, COM902 and pembrolizumab in advanced heavily pre-treated patients with platinum resistant ovarian cancer (PROC) has been published as an abstract released by the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) (Press release, Compugen, NOV 5, 2024, View Source [SID1234647713]).
This data and additional clinical data will be presented by Oladapo Yeku, M.D., Ph.D., FACP, Assistant Professor of Medicine, Harvard Medical School, and Director of Translational Research, Gynecologic Oncology Program, Massachusetts General Hospital, Boston, MA, and an investigator in this study, as a poster presentation at the 39th Annual Meeting of SITC (Free SITC Whitepaper), taking place between November 8-10, 2024 in Houston, Texas.
"The data from this study along with data Compugen previously presented, demonstrate that COM701 is active, has a favorable safety profile, and is a differentiated immune checkpoint inhibitor. COM701 in combination with COM902 (Fc reduced anti-TIGIT) and pembrolizumab (anti-PD-1) resulted in durable objective responses in late-stage ovarian cancer patients typically not responsive to other immunotherapeutic agents," said Dr. Oladapo Yeku. "There is a significant unmet need for effective, durable, and tolerable treatment options for patients with relapsed ovarian cancer. I look forward to discussing this data in Houston at SITC (Free SITC Whitepaper) on Friday, November 8, 2024 and participating in further clinical development of COM701."
Anat Cohen-Dayag, Ph.D. President, and Chief Executive Officer of Compugen added, "We are highly encouraged by the consistency of the data between our two platinum resistant ovarian cancer studies demonstrating COM701 driven activity and safety profile in more than forty advanced and heavily pre-treated patients. We believe these data support our initial observation of the unique mechanism of action of COM701 translating into clinical benefit in patients with ovarian cancer. We are encouraged by feedback from ovarian cancer experts supporting advancing COM701 to an earlier setting of ovarian cancer therapy based on its overall activity, safety profile and durability demonstrated in advanced disease. There is a gap in care for women with platinum sensitive ovarian cancer, who respond to chemotherapy but are ineligible for or cannot tolerate additional maintenance treatment. These patients have a less compromised immune system, providing the opportunity to harness the unique mechanism of action of COM701 to potentially change the disease trajectory improving progression free survival."
Dr. Cohen-Dayag continued, "Our development path in earlier lines of ovarian cancer will start by addressing this unmet need. I look forward to discussing these data and our future development plans including a fireside chat with Dr. Yeku, as part of our third quarter conference call that will take place on November 12, 2024, at 8:30 am ET."
The abstract is now available on the publication section of Compugen’s website. The poster and short video presentation of the poster by Dr. Yeku will be available on the publication section of Compugen’s website on Friday November 8, 2024.
SITC 2024 abstract
Data cut off: May 16, 2024
Note: The poster to be presented at SITC (Free SITC Whitepaper) on November 8, 2024 will include additional data
Treatment
COM701+COM902+pembrolizumab
No. patients
23 (efficacy evaluable)
Confirmed ORR
17.4% (1 CR, 3 PR)
Confirmed DCR
43.5%
Immune activation
Increase in peripheral IFNγ
Safety
Majority AEs GR ≤2
No GR 4/5 AEs
1 GR 3 event, serious immune related encephalopathy resolving following treatment with steroids
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