On May 8, 2024 Coeptis Therapeutics Holdings, Inc. (Nasdaq: COEP) (the "Company" or "Coeptis"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, autoimmune, and infectious diseases, reported that the Company has been selected for an oral presentation of the abstract titled Developing A First-In-Class Universal Allogeneic Snap-Car NK Cell Therapy at the International Society for Cell & Gene Therapy 2024, being held May 28th to June 1st in Vancouver, Canada (Press release, Coeptis Therapeutics, MAY 8, 2024, View Source [SID1234642910]).
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The Company’s SNAP-CAR platform technology has demonstrated its potential as a "universal" CAR therapy with the potential to target multiple antigens through combinatorial use of different adaptors, thus potentially avoiding toxicities and relapse due to antigen loss. In Q3 of 2023, Coeptis expanded its exclusive license agreement with the University of Pittsburgh for SNAP-CAR to include natural killer (NK) cells.
The background and aim of the abstract revolve around chimeric antigen receptor (CAR) expression by engineered NK cells and the ability to improve their innate anti-tumor functions by specifically activating NK cells in the presence of tumor antigen. Backed by research performed in conjunction with the University of Pittsburgh and Deverra Therapeutics, allogeneic CAR NK cells may be a safer, more clinically accessible, and cost-effective cellular therapy than autologous CAR T-cells. Based on the demonstrated successful use of a novel SNAP-CAR technology in T-cells, the Company is developing a first-in-class universal allogeneic SNAP-CAR NK cell. This product replaces the antigen binding domain of a CAR with a SNAP tag enzyme that carries out a self-labeling reaction to covalently attach any antibody conjugated to a benzylguanine (BG) tag to create a functional antigen-specific CAR.
"ISCT 2024 is a prestigious gathering renowned for fostering groundbreaking ideas and innovation," said Dave Mehalick, President and CEO of Coeptis Therapeutics. "Our presentation represents a significant and meaningful path forward in advancing our mission to develop a proprietary, allogeneic cell generation platform aimed at universalizing the treatment of many debilitating diseases."
Details of the presentations are outlined below:
TITLE: DEVELOPING A FIRST-IN-CLASS UNIVERSAL ALLOGENEIC SNAP-CAR NK CELL
PRESENTATION TYPE: Oral, Thursday, May 30, 2024 at 8am
AUTHORS: Carrie Stoltzman, Erika von Euw, Braxton Jamison (presenting author), Emily Hsieh, Kevin Green, Lara Ionescu Silverman, Dan Yerace, Dave Mehalick, Colleen Delaney
INSTITUTIONS: Deverra Therapeutics, Seattle, WA, United States
Coeptis Therapeutics, Wexford, PA, United States
The International Symposium on Cell and Gene Therapy (ISCT) brings together leading researchers, clinicians and industry experts in cell and gene therapy from around the world. Serving as a nexus for collaboration, the conference promotes the exchange of new scientific advances, technological advances and clinical insights in the rapidly developing field of cell and gene therapy. For more information: www.isctglobal.org/isct2024.