On July 31, 2023 Celloram Inc., a dynamic biotech startup based in Cleveland, Ohio and developing novel medicines for cancer and immune disorders, reported a groundbreaking licensing agreement with French biotech GENFIT SA to advance Celloram’s first-in-class inflammasome inhibitor, CLM-022 (Press release, Celloram, JUL 31, 2023, View Source [SID1234633558]). The agreement grants GENFIT exclusive global rights to develop CLM-022 in liver disease indications.
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"This exclusive licensing agreement with GENFIT aims to expand our inflammasome inhibitor platform into liver disease indications for the first time," said Tej Pareek, Ph.D., Celloram CEO. "We believe that GENFIT has the potential to rapidly advance the development of this class of inhibitors, ultimately bringing therapies and hope to a large population of patients who desperately need life-saving treatments. We are thrilled to work alongside GENFIT, a leading biopharmaceutical company, to bring this potential life-saving treatment to patients worldwide."
As part of this agreement, GENFIT will not only add to its arsenal of drug candidates for liver disease, but also gain access to Celloram’s scientists and medicinal chemistry expertise to help synthesize and validate CLM-022 as GENFIT advances on its goal to secure an IND for future clinical trials.
In recognition of this transformative collaboration, Celloram Inc. is eligible to receive up to €160 million in clinical, regulatory, and commercial milestone payments, which will further fuel its mission to deliver cutting-edge solutions for critical medical challenges. Celloram co-founders, Dr. John Letterio and Dr. Seong-Jin Kim, jointly stated, "Our vision at Celloram Inc. has always been driven by a passion for revolutionizing patient care by creating safer, more effective therapies. With this licensing agreement, we are one step closer to realizing Celloram’s vision and we are grateful for the opportunity to partner with GENFIT."
About Liver Disease
Liver disease is a progressive deterioration of liver functions lasting more than six months, involving synthesis of clotting factors, detoxification, and bile excretion. The process entails inflammation, destruction, and regeneration of liver parenchyma, often leading to fibrosis and cirrhosis. Etiologies are diverse, encompassing toxins, prolonged alcohol abuse, infections, autoimmune diseases, and genetic/metabolic disorders. The global liver disease treatment market size is predicted to be worth 25.8.3 billion USD by 2028 from 14.1 billion USD in 2023 to grow at a CAGR of 11.72% in forecasted period. Increasing cases of acute and chronic liver diseases, including liver cancer, are driving the demand for advanced liver disease diagnostics and treatments.