On October 5, 2022 ChemoCentryx, Inc., (Nasdaq: CCXI), reported two upcoming poster presentations for CCX559, the Company’s investigational, highly potent, orally administered PD-L1 checkpoint inhibitor, at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, held November 8-12, 2022, in Boston, MA (Press release, ChemoCentryx, OCT 5, 2022, View Source [SID1234621736]).
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ChemoCentryx Poster Presentations at SITC (Free SITC Whitepaper) 37th Annual Meeting (November 8-12, 2022):
Results From an Ongoing Open-Label, Multicenter, Phase 1 Trial of CCX559, an Orally Administered Small Molecule PD-L1 Inhibitor, in Patients with Advanced Solid Tumors
Abstract Number: 769
Location: Hall C
Presentation Time: November 10, 2022, 11:40 a.m. – 1:10 p.m. ET
Poster Viewing Time: November 10, 2022, 9:00 a.m. – 9:00 p.m. ET
The Small Molecule PD-L1 Inhibitor CCX559 Preferentially Accumulates in Tumors, Resulting in Depletion of Cell-Surface PD-L1 in a Murine Preclinical Model
Abstract Number: 499
Location: Hall C
Presentation Time: November 10, 2022, 11:40 a.m. – 1:10 p.m. ET
Poster Viewing Time: November 10, 2022, 9:00 a.m. – 9:00 p.m. ET
About CCX559
CCX559 is a highly potent orally administered small molecule PD-L1 checkpoint inhibitor. Preclinical characterization has demonstrated that CCX559 blocks binding to PD-1 and CD80, and prevents PD-L1 inhibition of T cell activation. CCX559, when orally administered in animal models, demonstrated anti-tumor efficacy, including the ability to induce complete responses.
The PD-L1/PD-1 interaction is one of the major immune checkpoints that limits the ability of effector T cells to destroy cancer cells. As a potential next generation therapy, an orally administered small molecule inhibitor of PD-L1 could have advantageous properties compared to approved monoclonal antibodies, such as better penetration into solid tumors, reduced immunogenicity, lack of Fc-mediated side effects and convenience of oral administration.
During 2021, ChemoCentryx initiated a first-in-human Phase I dose escalation study to evaluate the safety, tolerability, PK, and PD of CCX559 in patients with various types of advanced cancer. In early 2023, the Company plans to advance CCX559 into a Phase Ib/II clinical trial to measure anti-tumor effects of CCX559 more directly.