On December 12, 2022 CellCentric, a privately owned, clinical stage biotechnology company pioneering small molecule inhibition of p300/CBP to treat cancer, reported clinical data for the first time at the 64th American Society of Haematology (ASH) (Free ASH Whitepaper) Annual Meeting, New Orleans (Press release, CellCentric, DEC 12, 2022, View Source [SID1234625151]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
To date, 26 patients with relapsed/refractory multiple myeloma (RRMM) have been treated with inobrodib as monotherapy, including seven most recently at the recommended phase 2 dose and dose schedule (RP2D). Treatment has been generally well-tolerated with the majority of on-target toxicities being mild or moderate in severity.
Among the patients treated at the RP2D, six out of seven patients had reduction or stabilisation of serum free light chains. One patient saw an unconfirmed Complete Response (CR), which went on to become a durable confirmed Very Good Partial Response (VGPR); a second patient demonstrated a confirmed Partial Response (PR); and a third currently has an unconfirmed PR (by IMWG response criteria). These three patients remain on treatment after more than eight months.
Dose escalation in combination with pomalidomide and dexamethasone has been initiated in heavily pre-treated RRMM patients. Despite all three initial patients being pomalidomide-refractory, all showed a degree of response after the first cycle of treatment: 1 VGPR, 1 PR and 1 MR (serum M-protein 34% decrease).
Tim Somervaille, the Chief Investigator of Study CCS1477-02, CellCentric’s Phase 1 / 2, international haematological malignancy study, and Professor of Haematological Oncology at Cancer Research UK Manchester Institute and The University of Manchester, and Honorary Consultant Haematologist at The Christie NHS Foundation Trust said: "We are excited with these initial clinical results, which show inobrodib has the potential to offer patients with advanced multiple myeloma an additional treatment option. Furthermore, the preclinical data also presented today outlines and supports the hypothesis that targeting p300/CBP with inobrodib represents an entirely novel therapeutic strategy in this disease setting. Taken together, these findings provide clear encouragement for the further clinical development of this first in class drug."
Paul Richardson, Director of Clinical Research and Clinical Program Leader of the Jerome Pippe Myeloma Center and the RJ Corman Professor of Medicine, Harvard Medical School and Dana Farber Cancer Institute added: "This is encouraging early progress in a relapsed and refractory myeloma patient population that has significant unmet medical needs. Demonstrating clear monotherapy activity is important, but so too is seeing promising initial signs of combinability with existing standards of care, which typically serve as backbone agents in this setting."
Leif Bergsagel, Professor of Medicine for the Mayo Clinic College of Medicine, and a consultant in the Division of Hematology and Medical Oncology, Department of Internal Medicine, at Mayo Clinic, Arizona said: "Inobrodib has an interesting, new mode of action, and importantly is also an oral agent. Ease of use is a key consideration as we look for the widest adoption of new treatments in the community."
Presentation details
Potent Pre-Clinical and Early Phase Clinical Activity of EP300/CBP Bromodomain Inhibitor CCS1477 in Multiple Myeloma
Session Name: 651. Multiple Myeloma and Plasma Cell Dyscrasias: Basic and Translational
Session Date, Time: Saturday, December 10, 2022, 4:00 PM
Room: Ernest N. Morial Convention Center, New Orleans Theater C
Publication Number: 349
About inobrodib:
CellCentric has developed inobrodib from concept through to clinical trials. It is an oral, first in class small molecule inhibitor drug that targets twin cancer gene regulators p300 and CBP. Inhibiting p300/CBP impacts the expression of key cancer drivers including MYC and IRF4 which are particularly important in the progression of certain blood cancers. In addition, inobrodib impacts the androgen receptor pathway. CellCentric has demonstrated that its pioneering drug, inobrodib, has a direct impact on these key oncogenes both pre-clinically and in tumour samples.
Inobrodib is formulated as an oral capsule which, along with its manageable safety profile, allows for administration at home.
As well as testing in heavily pre-treated, relapsed refractory haematological malignancy patients, CellCentric also has a study evaluating inobrodib in solid tumours, including late stage prostate cancer (mCRPC).