On September 2, 2021 Redx Pharma plc (AIM: REDX), the drug discovery and development company focused on cancer and fibrosis, reported that a milestone payment of $3 million from Jazz Pharmaceuticals plc (NASDAQ: JAZZ) has been triggered as a result of the initiation of IND-enabling studies of JZP815, a preclinical Pan-RAF inhibitor, for the potential treatment of RAF driven tumours (Press release, Redx Pharma, SEP 2, 2021, View Source [SID1234587167]). Mutations leading to uncontrolled signalling in the RAS-RAF-MAPK pathway are seen in around one third of all cancers.

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The milestone payment is due under the agreement with Jazz Pharmaceuticals announced on 10 July 2019 for Redx’s Pan-RAF inhibitor. Under the deal, Redx is entitled to up to $203 million in development, regulatory and commercial milestone payments. The Company is also eligible for royalties based on any future net sales. The next milestone payment under the agreement is due on acceptance of an Investigational New Drug (IND) application by the U.S. Food and Drug Administration (FDA). As part of a separate ongoing collaboration agreement, Jazz paid Redx to perform research and preclinical development activities to progress the programme to this stage, with the goal of completing IND-enabling studies.

The Pan-RAF inhibitor programme aims to overcome resistance mechanisms associated with clinically approved B-RAF selective drugs. The RAF kinases A-RAF, B-RAF and C-RAF are an integral part of the RAS-RAF-MAPK pathway, with B-RAF mutations commonly seen in the clinic. Although most B-RAF V600E/K mutant skin cancers are initially sensitive to approved B-RAF selective drugs, treatment resistance often develops leading to disease progression. Moreover, B-RAF V600E mutant colorectal cancers are surprisingly insensitive to these B-RAF selective drugs as single agents due to the functions of other RAF family members. Importantly, B-RAF selective therapies fail to show clinical benefit against the more prevalent RAS-mutated tumours. This Pan-RAF inhibitor aims to overcome these resistance mechanisms.

Lisa Anson, Chief Executive Officer of Redx Pharma commented: "We are extremely pleased that Jazz Pharmaceuticals has initiated IND-enabling studies for the Pan-RAF inhibitor programme that Jazz acquired. The continuing success of this programme highlights, once again, Redx’s ability to generate molecules that have significant potential as novel medicines for unmet medical needs."

On September 2, 2021 Turning Point Therapeutics, Inc. (NASDAQ: TPTX), a precision oncology company developing next-generation therapies that target genetic drivers of cancer, reported that President and CEO Athena Countouriotis, M.D., will participate in the Wells Fargo Virtual Healthcare Conference on Sept. 9 and the H.C. Wainwright 23rd Annual Global Investment Conference on Sept. 13 (Press release, Turning Point Therapeutics, SEP 2, 2021, View Source [SID1234587185]).

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Dr. Countouriotis is scheduled to present a company overview and participate in a question-and-answer session at 2:00 p.m. ET on Sept. 9 and present a company overview at 7:00 a.m. ET on Sept. 13. Both sessions will be accessible via webcast through the Investors page of www.tptherapeutics.com.

On September 2, 2021 The Jerome Canady Research Institute for Advanced Biological and Technological Sciences (JCRI-ABTS), in collaboration with US Medical Innovations, LLC (USMI), reported that they have discovered the mechanism using Canady Helios Cold Plasma (CHCP) to induce cell death in breast cancer (Press release, JCRI-ABTS, SEP 2, 2021, View Source [SID1234587202]).

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Recently accepted for publication in the International Journal of Molecular Sciences, the article "Canady Helios Cold Plasma Induces Breast Cancer Cell Death by Oxidation of Histone mRNA" described how research scientists at JCRI/ABTS treated four (4) breast cancer cell lines with Canady Helios Cold Plasma (CHCP) at different dosages and monitored the progress of apoptosis (cell death).

Jerome Canady, MD (CEO of USMI), stated "As we have proven, CHCP is a very promising adjuvant therapy to selectively combat many cancers, but our focus in this report is our work on breast cancer which affects over 3.5 million women in the US alone. Inhibition of cell proliferation, induction of apoptosis, and disruption of cell cycle were all observed during the early S-phase of the cell cycle. This news is auspicious because it shows CHCP treatment can be personalized for specific breast cancer types."

Canady Helios Cold Plasma or CHCP is a highly selective, non-thermal process developed by USMI for treating solid cancerous tumors during the surgical procedure. CHCP triggers both chemical and molecular changes in the cancer cells that cause significant stress and drastically decreases the cancer cell’s viability, leading to apoptosis. CHCP is proven to be safe and causes no thermal injury to normal tissue.

JCRI-ABTS and USMI have recently completed the first FDA-approved Phase I Clinical Trial to evaluate Cold Atmospheric Plasma for the treatment of cancer (IDE #190165). The clinical sites were Rush University Medical Center (Chicago, IL) and Sheba Medical Center (Ramat Gan, Israel)).

More information will be shared when Dr Canady presents at the annual Baird Global Healthcare Conference on September 14th at 10:15 AM ET.

On September 2, 2021 Epigenomics AG (Frankfurt Prime Standard: ECX, OTCQX: EPGNY; the "Company") reported that a study recently published in BMC Cancer shows that blood tests, such as Epi proColon(R), can significantly increase the CRC screening rates in medically underserved populations (MUP) unwilling or unable to complete FIT or colonoscopy. For eligible participants, the rate of testing increased from 12.6% completing a FIT test the previous year to 93.5% with the blood test.

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Greg Hamilton, CEO of Epigenomics AG, commented: "CRC still is the second leading cause of cancer mortality in the U.S., despite the ability to reduce it through screening. Adherence to regular screening is key to earlier CRC detection thus reducing incidence and mortality. The findings now being published are in line with a series of previously published results that blood tests can make an important contribution to reducing the number of CRC related deaths, especially in medically underserved populations which are the most vulnerable."

In the U.S., many people are not up-to-date with CRC screening despite the available testing, with overall screening rates under 70%. This applies in particular to MUP, who share characteristics such as low income, lack of insurance or being underinsured. Although FIT has desirable characteristics for MUP, return rates are consistently low, around 10% in MUP compared to the general population. This was confirmed in the study now published. In the study, the patients were consecutively offered CRC screening by colonoscopy and FIT, according to the current guidelines for CRC screening. Only when both options were rejected, the blood test was offered. Of the 460 participants ultimately offered screening, no participant accepted the offer of colonoscopy, 30 (6.5%) chose FIT screening and 430 (93.5%) elected for mSEPT9 testing. Only two of the 30 participants who chose FIT returned the test (6.7%).

Hence, the study results show that the introduction of blood-based testing for CRC screening, when compared to FIT, has proven to be well-received by the participants, likely because of convenience and ease of testing. The result is another important contribution to the realization that FDA approved CRC screening blood tests should be incorporated into the screening paradigm, as this is a tangible solution to reduce CRC mortality.

On September 2, 2021 CohBar, Inc. (NASDAQ: CWBR), a clinical stage biotechnology company developing mitochondria based therapeutics to treat chronic diseases and extend healthy lifespan, reported that its Chief Executive Officer, Dr. Joseph Sarret, will present a company overview at the following investor conferences in September (Press release, CohBar, SEP 2, 2021, View Source [SID1234587237]).

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H.C. Wainwright Annual Global Investment Conference
September 13 – 15, 2021
Webcast: The presentation may be accessed via webcast on demand using the following link: View Source

Cantor Fitzgerald Virtual Global Healthcare Conference
Thursday, September 30, 2021 at 2:00pm ET
Webcast: The presentation may be accessed via webcast at the scheduled time, or following the presentation, using the following link: View Source

A replay of the webcasts will be available in the events section of the CohBar website for two weeks following the presentation.