On November 1, 2017 Roche (SIX: RO, ROG; OTCQX: RHHBY) reported that new data on its approved and investigational medicines for blood diseases will be presented at the 59th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting from 9 – 12 December, in Atlanta (Press release, Hoffmann-La Roche, NOV 1, 2017, View Source [SID1234521400]). Ten Roche medicines will be featured in over 75 abstracts, including 26 oral presentations, across eight blood diseases.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
“At ASH (Free ASH Whitepaper) this year, we look forward to presenting a wealth of data highlighting potential advances across the spectrum of blood diseases, from rare conditions like haemophilia A to common blood cancers like lymphoma,” said Sandra Horning, MD, Roche’s Chief Medical Officer and Head of Global Product Development. “Our ongoing development programme in haematology is one of the largest in this area, underscoring our commitment to developing practice-changing medicines and improving outcomes for people with diseases of the blood.”
Among Roche’s clinical data to be featured at ASH (Free ASH Whitepaper) are results from the ongoing trials for the investigational medicine emicizumab. Updated data with an additional six months of follow-up from the phase III HAVEN 1 and HAVEN 2 studies evaluating the safety and efficacy of emicizumab in adults, adolescents and children with haemophilia A with inhibitors will be presented. The HAVEN 2 study will be highlighted as part of ASH (Free ASH Whitepaper)’s official press program on 9 December at 07:30am EST. Additional results from the emicizumab clinical development programme will be presented during the meeting, including preliminary data from the phase III HAVEN 4 study exploring emicizumab prophylaxis administered every four weeks in people with haemophilia A with and without inhibitors, as well as real-world data from a non-interventional study in children under 12 years of age with haemophilia A with inhibitors.
Roche will also be sharing data for medicines in late-stage development for a range of blood cancers. Highlights include results from a randomised phase II study evaluating polatuzumab vedotin, an investigational anti-CD79b antibody drug conjugate, in combination with MabThera/Rituxan (rituximab) and bendamustine versus MabThera/Rituxan and bendamustine for the treatment of people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Based on data from this study, polatuzumab vedotin was recently granted Breakthrough Therapy Designation by the US Food and Drug Administration (FDA) and had previously received the PRIME (PRIority MEdicines) designation in Europe.
Additionally, results from studies of Gazyva/Gazyvaro (obinutuzumab), including new data from the
phase III GALLIUM study in previously untreated follicular lymphoma, and data from the phase III PrefMab study evaluating patient preference for the subcutaneous (SC) formulation of MabThera/Rituxan Hycela (rituximab/rituximab and hyaluronidase human) as a treatment for DLBCL and follicular lymphoma will also be shared. Finally, results from multiple studies assessing the safety and efficacy of Venclexta/Venclyxto (venetoclax) across chronic lymphocytic leukaemia (CLL), multiple myeloma (MM) and acute myeloid leukaemia (AML) will be presented. Venclexta/Venclyxto is being developed by AbbVie and Roche.
Key abstracts featuring Roche medicines that will be presented at ASH (Free ASH Whitepaper) can be found in the table below.
Follow Roche on Twitter via @Roche and keep up to date with ASH (Free ASH Whitepaper) Annual Meeting news and updates by using the hashtag #ASH17.