BerGenBio – Invitation to conference call: interim update on Ph II clinical programme with selective AXL inhibitor bemcentinib being presented at ASCO

On May 29, 2018 BerGenBio ASA (OSE: BGBIO) reported it will host a conference call on Monday, 4 June at 8:30 AM CEST to present updated interim clinical and biomarker results from its ongoing Phase II development programme with selective AXL inhibitor bemcentinib (Press release, BerGenBio, MAY 29, 2018, View Source [SID1234527034]). The data will be presented at the Annual American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) meeting and at a reception hosted by BerGenBio (details below).

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Conference call details:
The call will be hosted by BerGenBio senior management and take place on:
Monday, 4 June 2018 at 8:30 AM CEST.
To take part, please dial in 5-10 minutes prior to the scheduled start using below phone number and confirmation code 1068189:

Norway +47 2100 2608
United Kingdom +44 (0)330 336 9106
United States +1 323-794-2594

A slide deck presentation to accompany the call will be made available at www.bergenbio.com in the Investors / Presentations section from 8:00 AM CEST on 4 June 2018.

Presentations to be made during the annual ASCO (Free ASCO Whitepaper) meeting:
Saturday 2 June, 6:00 – 8:00 PM CDT, Chicago School of the Art Institute, Chicago, IL
BerGenBio private reception

New interim Phase II clinical trial data with bemcentinib and selected pre-clinical data to be discussed by BerGenBio principal investigators and invited key opinion leaders
For further details and to receive an invitation, please click here
Monday 4 June, 8:00 AM – 11:30 AM CDT, ASCO (Free ASCO Whitepaper) Annual Meeting, McCormick Center, Chicago, IL

Interim clinical data from clinical trial ref. BGBC008 – Poster Board: #292, Abstract 3078
Interim clinical data from clinical trial ref. BGBC003 – Poster Board: #80, Abstract 7020
To be discussed at the Poster Discussion Session. 11:30 AM – 12:45 PM
Biomarker study – Poster Board: #385, Abstract 2559
Monday 4 June, 1:15 PM – 4:45 PM CDT, ASCO (Free ASCO Whitepaper) Annual Meeting, McCormick Center, Chicago, IL

Interim clinical data from clinical trial ref. BGBIL006 – Poster Board: #375, Abstract 9548
The posters presented at ASCO (Free ASCO Whitepaper) will be made available www.bergenbio.com in the Investors / Presentations section at the time of presentation.

AbbVie to Present at the Goldman Sachs 39th Annual Global Healthcare Conference

On May 29, 2018 AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, reported it will participate in the Goldman Sachs 39th Annual Global Healthcare Conference on Tuesday, June 12, 2018 (Press release, AbbVie, MAY 29, 2018, View Source [SID1234527051]). Richard A. Gonzalez, chairman and chief executive officer, will present at 10 a.m. Central time.

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A live audio webcast of the presentation will be accessible through AbbVie’s Investor Relations website at investors.abbvie.com. An archived edition of the session will be available later that day.

Onconova Therapeutics, Inc. to Present at the 8th Annual LD Micro Invitational

On May 29, 2018 Onconova Therapeutics, Inc. (NASDAQ: ONTX), a Phase 3-stage biopharmaceutical company focused on discovering and developing novel small molecule drug candidates to treat cancer, with a primary focus on Myelodysplastic Syndromes (MDS), reported that it will be presenting at the 8th Annual LD Micro Invitational on Monday, June 4th at 9:00a PDT / 12:00p EDT at the Luxe Sunset Bel Air Hotel in Los Angeles (Press release, Onconova, MAY 29, 2018, View Source [SID1234527102]). Mr. Mark Guerin, Chief Financial Officer of Onconova, will be giving the presentation and meeting with investors.

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"The event is slated to be our largest Invitational to date," stated Chris Lahiji, President of LD Micro. "When the fires caused the cancellation of our Main Event back in December, we vowed to come back even stronger. This event showcases our firm’s ability to attract the most unique and exciting names in micro-cap."

The conference will feature 230 companies in the small-cap / micro-cap space, and will be attended by over 1,000 individuals.

Oncoceutics Abstracts at ASCO Highlight Efficacy of ONC201 in High-Grade Gliomas

On May 29, 2018 Oncoceutics, Inc. reported that two abstracts will be presented at the 2018 Annual Meeting of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) that will highlight clinical success of the company’s lead compound in treating high-grade gliomas (HGG), including those that harbor the H3 K27M mutation (Press release, Oncoceutics, MAY 29, 2018, View Source [SID1234558368]).

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The first abstract, entitled "Integrated clinical experience with ONC201 in H3 K27M glioma," describes preliminary clinical data indicating ONC201 induces durable radiographic regressions and clinical benefit in patients with HGG that harbor the H3 K27M mutation. This mutation is prevalent among certain types of brain tumors that develop in children and young adults and is known to confer one of the most dismal and uniformly lethal prognoses amongst HGG. There is no proven medical therapy for these patients. The integrated cohort of H3 K27M-mutant glioma patients who have received ONC201 that will be reported at the meeting include children and adults with different tumor locations. The durability of regressions and clinical benefit will be reported, which is an important measure of efficacy in this disease that is consistent with the immunostimulatory activity of ONC201 that was recently reported in the Journal of Clinical Investigation. ONC201 is currently being evaluated in pediatric and adult H3 K27M-mutant gliomas in three ongoing clinical trials at several institutions around the United States: NCT03416530, NCT03295396, NCT02525692.

The second abstract, entitled "Intratumoral activity of ONC201 in adult recurrent glioblastoma patients" describes the concentrations, targeted signaling pathways, and apoptosis associated with ONC201 directly within tumors that have been surgically removed from adult recurrent glioblastoma patients who have received two doses ONC201. These results serve as an important complement to macroscopic clinical imaging by enabling microscopic studies that demonstrate the drug is inducing the intended therapeutic impact that causes tumor cells to undergo cell death.

In addition to the two abstracts focused on HGG, there is another abstract that reports the safety and pharmacodynamics of ONC201 in advanced solid tumor patients. Additional results support the conclusion that weekly, oral ONC201 is well-tolerated and results in prolonged stable disease, intratumoral apoptotic signaling and immunomodulatory activity.

The abstracts are listed below.

2059. Integrated clinical experience with ONC201 in H3 K27M glioma. Presented Saturday, June 2, 2018.

E14034. Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.

2595. Safety and pharmacodynamics of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration. Presented Monday, June 4, 2018,

10-K – Annual report [Section 13 and 15(d), not S-K Item 405]

MetaStat has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission (Filing, 10-K, MetaStat, 2018, MAY 29, 2018, View Source [SID1234526920]).

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