On January 8, 2018 Regeneron Pharmaceuticals, Inc. presented Presentation by Robert E. Landry, Senior Vice President, Finance and Chief Financial Officer of Regeneron Pharmaceuticals, Inc., entitled "2018 Financial Overview (Presentation, Regeneron, JAN 8, 2018, View Source [SID1234523001])."

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On January 8, 2018 Acceleron Pharma Inc. presented Slide presentation of dated January 2018 (Presentation, Acceleron Pharma, JAN 8, 2018, View Source [SID1234522997]).

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On January 8, 2018 Idera Pharmaceuticals presented Corporate presentation at 36th Annual J.P. Morgan Healthcare conference (Presentation, Idera Pharmaceuticals, JAN 8, 2018, View Source [SID1234523009]).

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On January 8, 2018 Mateon Therapeutics, Inc. (OTCQX:MATN), a biopharmaceutical company developing investigational drugs for the treatment of orphan oncology indications, reported new preclinical data further characterizing the improved anti-tumor immune response observed when animals are treated with CA4P in combination with anti-CTLA-4 antibodies (Press release, Mateon Therapeutics, JAN 8, 2018, View Source [SID1234523012]).

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The new findings show that treatment with the combination of CA4P and an anti-CTLA-4 antibody nearly doubles the amount of tumor necrosis (mean = 63.9%) compared to treatment with an anti-CTLA-4 antibody alone (32.8%), CA4P alone (37.3%) or vehicle control (25.8%) in a preclinical CT-26 mouse colon cancer model using immunohistochemistry analyses. Results from these analyses confirmed previously announced findings showing that treatment with CA4P and an anti-CTLA-4 antibody resulted in increased overall median numbers of tumor infiltrating CD8+ T lymphocytes. The new preclinical data also showed that the distribution of these beneficial CD8+T lymphocyte cells was observed throughout the tumor – in both the tumor rim and tumor core.

"These new data further show the promise of CA4P to stimulate the immune system and enhance the efficacy of checkpoint inhibitors," said William D. Schwieterman, M.D., President and Chief Executive Officer of Mateon Therapeutics. "We are excited that CA4P, when combined with a checkpoint inhibitor, shows dramatic increases in tumor necrosis which are clearly correlated with an increased immunologic response, more tumor regressions and increased overall survival. Given these new findings, the large clinical safety database for CA4P, and the need for new therapies for the many patients who have not responded to checkpoint inhibitor therapy, we believe CA4P has great promise for use with these immuno-oncology agents."

About Checkpoint Inhibitors

Anti-CTLA-4 antibodies stimulate a patient’s immune system by blocking immunosuppression and include the approved anti-cancer drug Yervoy. Mateon’s investigational drug CA4P stimulates a patient’s immune system in a different but complementary manner – by inducing immediate, rapid and extensive tumor cell necrosis. Utilizing these two different but complementary immune-stimulating approaches simultaneously has the potential to improve patient outcomes for the majority of cancer patients that do not respond adequately to therapy with checkpoint inhibitors alone.

About CA4P With Checkpoint Inhibitors

Mateon previously reported data from a CT-26 colon cancer animal model showing that combination treatment with CA4P and an anti-CTLA-4 antibody causes large reductions in tumor volume and statistically significant improvements in survival when compared to anti-CTLA-4 alone, CA4P alone, or vehicle control. Similar anti-tumor effects were observed when this combination was studied in an EMT-6 mammary tumor animal model. The CT-26 model was repeated for the studies reported today, again showing large reductions in tumor volume with combination therapy and also indicating a heightened immunologic response to the tumor in the presence of the two-drug combination. Importantly, treatment with both CA4P and an anti-CTLA-4 antibody generally maintains an elevated tumor-associated median effector T cell/regulatory T cell ratio, which also indicates a heightened immune response. Work to further characterize the immune response seen with the combination is ongoing.

On January 8, 2018 BeiGene, Ltd. (NASDAQ: BGNE), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly targeted and immuno-oncology drugs for the treatment of cancer, and Mirati Therapeutics (NASDAQ: MRTX), a clinical-stage targeted oncology company, reported an exclusive license agreement for the development, manufacturing and commercialization of Mirati’s sitravatinib in Asia (excluding Japan), Australia, and New Zealand (Press release, Mirati, JAN 8, 2018, View Source [SID1234523062]). Mirati will retain exclusive rights for the development, manufacturing and commercialization of sitravatinib for the rest of world.

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Sitravatinib is an investigational tyrosine kinase inhibitor that has demonstrated potent inhibition of receptor tyrosine kinases (RTKs), including TAM family receptors (TYRO3, Axl, MER), split family receptors (VEGFR2, KIT) and RET. It is being evaluated by Mirati as a single agent in a Phase 1b expansion trial in patients whose tumors harbor specific genetic alterations in non-small cell lung cancer (NSCLC) and other tumors types. Sitravatinib has shown encouraging interim results in an ongoing Phase 2 trial in combination with nivolumab in NSCLC patients who have progressed after prior treatment with a checkpoint inhibitor.

"We are delighted to enter into this exclusive clinical development and commercialization agreement for sitravantinib and look forward to working with the experienced team at Mirati. Sitravatinib is an exciting compound that has demonstrated a unique tyrosine kinase inhibition profile and promising clinical activity both as a single agent and in combination with a checkpoint inhibitor in non-small cell lung cancer. This collaboration complements our portfolio and will allow us to investigate sitravatinib in

combination with tislelizumab, our investigational anti-PD-1 antibody, in China and the rest of the licensed territory," commented John V. Oyler, Founder, Chief Executive Officer, and Chairman of BeiGene.

"We are excited to begin a partnership with BeiGene, which has built a world-class global development organization with a strong presence in Asia-Pacific, as well as an established commercial organization in China. They have demonstrated an ability to enroll patients quickly in a variety of indications which will augment our development capabilities and expand the evaluation of sitravatinib to additional tumor types for patients who are checkpoint inhibitor naïve or who have been previously treated with a checkpoint inhibitor," said Charles M. Baum, M.D., Ph.D., President and Chief Executive Officer of Mirati Therapeutics.

Under the agreement Mirati will receive an upfront cash payment of $10 million from BeiGene. Additionally, Mirati is eligible to receive up to $123 million of additional payments based upon the achievement of certain development, regulatory and sales milestones as well as significant royalties on future sales of sitravatinib in the licensed territory.