Onxeo to Present at BIO International Convention in Boston

On May 23, 2018 Onxeo S.A. (Euronext Paris, NASDAQ Copenhagen: ONXEO FR0010095596), a biotechnology company specializing in the development of innovative drugs in oncology, notably against rare or resistant forms of cancer, reported that Judith Greciet, the Company’s Chief Executive Officer, will present at the 25th BIO International Convention (Press release, Onxeo, MAY 23, 2018, View Source [SID1234526866]). The conference is being held on June 4-7, 2018, in Boston, MA.

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The BIO International Convention is hosted by the Biotechnology Innovation Organization (BIO). It is attended by more than 1,100 biotechnology and pharmaceutical companies, academic institutions, state biotechnology centers and related organizations across the United States and from over 30 countries worldwide.

Onxeo corporate presentation:

Date: June 4th, 2018

Time: 3 pm EST / 9 pm CEST

Location: Theater 2 – Boston Convention & Exhibition Center: 415 Summer St., Boston, MA

180523_ONXEO_PR_EN_BIO

DelMar Appoints Saiid Zarrabian to Full-Time President and CEO

On May 22, 2018 DelMar Pharmaceuticals, Inc. (the "Company")(NASDAQ: DMPI) reported that the board of directors (the "Board") has appointed Saiid Zarrabian as the full-time President and Chief Executive Officer of the Company, effective immediately (Press release, DelMar Pharmaceuticals, MAY 22, 2018, View Source [SID1234526845]). Mr. Zarrabian had previously served as the Company’s interim President and Chief Executive Officer since November 2017 and prior to that as an independent board member since July 2017.

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"Saiid has made significant contributions to DelMar, initially as an independent board member and, most recently, as DelMar’s interim President and CEO. We are pleased that he has agreed to further commit to the Company by taking on the full-time President and CEO role, effective immediately. His contributions have included a renewed focus on our two Phase 2 open label trials for MGMT-unmethylated glioblastoma multiforme, and enhanced fiscal responsibility while advancing our clinical programs in a timely and cost-effective fashion. The Board and I look forward to working with him to build on this momentum," stated Dr. Erich Mohr, Chairman of the Board.

"I am excited to transition from my interim role at DelMar and to continue the clinical advancement of VAL-083, which has been validated in over 40 prior clinical trials indicating VAL-083’s potential to combat multiple devastating diseases for patients with limited alternatives. Although VAL-083 may have applicability to many other solid tumor indications with potentially significant future commercial opportunities, we intend to use a disciplined and stepped approach to investing our resources in pursuing such opportunities. Over the next year, we expect to achieve a number of clinical milestones for VAL-083, including data from the ongoing Phase 2 second-line recurrent GBM study at MD Anderson, as well as data from the international Phase 2 study in newly diagnosed GBM patients. We plan to use our current capital efficiently and to continue to drive the enrollment of our clinical studies in an effort to maximize value for our shareholders," said Mr. Zarrabian.

Mr. Zarrabian is a successful veteran of the biotechnology industry. He previously served as chairman of the board of directors at La Jolla Pharmaceutical Company during the company’s transition from being an OTC listed company to a Nasdaq traded company. He also served as president of the Protein Production Division of Intrexon Corporation, a synthetic biology company. Prior to that, he served as chief executive officer and a member of the board of directors of Cyntellect, Inc., a stem cell processing and visualization instrumentation company until it was acquired in 2012. He served as president and chief operating officer of Senomyx, Inc., a company focused on discovery and commercialization of new flavor ingredients, and as chief operating officer of Pharmacopeia, Inc., a former publicly-traded provider of combinatorial chemistry discovery services and compounds, where he also served as president and chief operating officer of its MSI Division. In addition, Mr. Zarrabian has served on numerous private and public company boards, including at Immune Therapeutics, Inc., Exemplar Pharma, LLC, Ambit Biosciences Corporation, eMolecules, Inc. and Penwest Pharmaceuticals Co. Currently, he is serving as an advisor to Redline Capital Partners, S.A., a Luxemburg-based investment firm.

Aileron Therapeutics Announces Publication of ALRN-6924 Nonclinical Data in T-cell Lymphomas by Researchers at Dana-Farber Cancer Institute

On May 22, 2018 Aileron Therapeutics (Nasdaq:ALRN), the leader in the field of stapled peptide therapeutics for cancers and other diseases, reported the publication of nonclinical results in Nature Communications demonstrating the anti-cancer potential of ALRN-6924 in models of T-cell lymphoma (TCL) (Press release, Aileron Therapeutics, MAY 22, 2018, View Source;p=RssLanding&cat=news&id=2350149 [SID1234526844]). ALRN-6924 is designed to reactivate p53-mediated tumor suppression by targeting the two primary p53 suppressor proteins, MDM2 and MDMX. ALRN-6924 is being evaluated in Phase 1 and Phase 2 clinical trials in patients with peripheral T-cell lymphoma (PTCL) and acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).

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As reported in the study, ALRN-6924 showed potent in vitro activity and superior in vivo activity across eight different patient-derived xenograft models, compared to the standard-of-care agent. Separately, it was noted in the publication that ALRN-6924 induced a complete remission in a patient with TP53-wild-type angioimmunoblastic T-cell lymphoma, demonstrating the potential for rapid translation of discoveries from preclinical models.

"These data independently confirm previous preclinical and clinical results that the stapled peptide ALRN-6924 possesses anti-cancer activity based on a novel mechanism of action—the dual inhibition of MDMX and MDM2, instead of the inhibition of MDM2 alone. In addition, these data further demonstrate that stapled peptides represent a new treatment modality with unique properties that enable the targeting of previously ‘undruggable’ targets," said Manuel Aivado, MD, PhD, Chief Medical and Scientific Officer of Aileron.

"We were very gratified by these results," said David Weinstock, MD, Principal Investigator and Associate Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School. "The xenograft models we created and tested provide significant insight into the activity of a drug like ALRN-6924 and how well it will work in patients. We’re excited to see this drug move forward in clinical trials and hope to better understand the best way to use it as either a single agent or in combinations."

The study in Nature Communications is titled, "Targetable Vulnerabilities in T- and NK-cell Lymphomas Identified Through Preclinical Models."

About ALRN-6924
ALRN-6924 is a first-in-class product candidate designed to reactivate wild type p53 tumor suppression by disrupting the interactions between the two primary p53 suppressor proteins, MDMX and MDM2. Aileron believes ALRN-6924 is the first and only product candidate in clinical development that can equipotently bind to and disrupt the interaction of MDMX and MDM2 with p53. Based on preclinical data and preliminary evidence of safety and anti-tumor activity in its ongoing clinical trials, there may be a significant opportunity to develop ALRN-6924 as a monotherapy or combination therapy for a wide variety of solid and liquid tumors. ALRN-6924 is currently being evaluated in multiple clinical trials for the treatment of acute myeloid leukemia (AML), advanced myelodysplastic syndrome (MDS) and peripheral T-cell lymphoma (PTCL). For information about its clinical trials, please visit www.clinicaltrials.gov.

10-K – Annual report [Section 13 and 15(d), not S-K Item 405]

Burzynski Research Institute has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission .

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AbbVie to Present at the Jefferies 2018 Global Healthcare Conference

On May 22, 2018 AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, reported it will participate in the Jefferies 2018 Global Healthcare Conference on Wednesday, June 6, 2018 (Press release, AbbVie, MAY 22, 2018, View Source [SID1234526846]). Bill Chase, executive vice president and chief financial officer, will present at 7:30 a.m. Central time.

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A live audio webcast of the presentation will be accessible through AbbVie’s Investor Relations website at investors.abbvie.com. An archived edition of the session will be available later that day.