On January 3, 2018 Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) reported that management will present at the J.P. Morgan Healthcare Conference on Monday, January 8, 2018 at 12:30 p.m. ET (9:30 a.m. PT) (Press release, Vertex Pharmaceuticals, JAN 3, 2018, View Source [SID1234522859]). The audio portion of management’s remarks can be accessed live through Vertex’s website, www.vrtx.com in the "Investors" section under the "News and Events" page.

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In addition, the company announced today that it will report its fourth-quarter and full-year 2017 financial results on Wednesday, January 31 after the markets close. In conjunction with the announcement, management will host a conference call that day at 4:30 p.m. ET. To participate in the conference call, please dial (866) 501-1537 (U.S.) or +1 (720) 545-0001 (International). The call will also be available as a live and archived webcast on Vertex’s website.

On January 4, 2018 IntelGenx Corp. (TSX VENTURE:IGX) (OTCQX:IGXT) (the "Company" or "IntelGenx") reported that its President and Chief Executive Officer, Dr. Horst Zerbe, is scheduled to present an overview of the Company’s business at the 10 th Annual Biotech Showcase conference on Tuesday, January 9 at 9:00 a.m. Pacific Time at the Hilton San Francisco Union Square Hotel (Press release, IntelGenx, JAN 3, 2018, View Source [SID1234522909]).

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The presentation will be webcast live and archived for 90 days on the Company’s website, at www.intelgenx.com , under "Investors".

Andre Godin , Executive Vice President and Chief Financial Officer, and Dr. Dana Matzen , Vice President Business and Corporate Development, from IntelGenx will also be available for one-on-one meetings in San Francisco from January 8 through 10 . To arrange an investor meeting with IntelGenx , please contact Stephen Kilmer ( [email protected] ) and to arrange a business development meeting please contact Dr. Laëtitia Rodes ( [email protected] ) .

On January 3, 2018 LabCorp (NYSE: LH) reported that it will participate at the 36th Annual J.P. Morgan Healthcare Conference (Press release, LabCorp, JAN 3, 2018, View Source;p=RssLanding&cat=news&id=2324630 [SID1234522842]). LabCorp’s presentation is scheduled for Tuesday, January 9, 2018 at 9:30 am (PT).

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A live audio webcast of the presentation will be available via the Company website at www.labcorp.com and archived for replay.

On January 2, 2018 NanOlogy, a clinical stage pharmaceutical development company, reported that Gere diZerega, MD, VP of Medical Affairs, will present at Biotech Showcase, January 8, 2018, at 3:45 pm in Franciscan room D on the Ballroom Level of the Hilton San Francisco Union Square Hotel (Press release, NanOlogy, JAN 2, 2018, View Source [SID1234522843]).

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Dr. diZerega will present an update on the status of the NanOlogy clinical development programs. The company is developing a submicron particle technology platform for local delivery of chemotherapeutic agents in the treatment of cancer and related illnesses via intratumoral, intracystic, intraperitoneal, and topical administration.

Clinical Programs
NanOlogy has four Phase 2 clinical trials underway for NanoPac, a sterile suspension of submicron particle paclitaxel, in ovarian cancer (with orphan drug designation), prostate cancer, pancreatic cancer, and pancreatic mucinous cysts. NanOlogy also is conducting a Phase 2 trial of SOR007, submicron particle paclitaxel suspended in a topical anhydrous base, for cutaneous metastases, while NanOlogy affiliate, DFB Soria, has a Phase 2 trial of SOR007 nearing completion for actinic keratosis.

Preclinical
In addition, NanoPac for nebulized inhalation has shown tumor reduction in a preclinical lung cancer study after pharmacokinetic studies demonstrated more than 14 day retention of drug in lung tissue. In 2018, clinical trials are planned for NanoDoce, a sterile suspension of the submicron particle docetaxel, pending IND approval.

Patent Portfolio
The NanOlogy submicron particle technology platform is protected by an extensive intellectual property (IP) portfolio covering production processes, uses, formulations, and specifications, as well as composition under US patent 9,814,685 entitled Taxane Particles and Their Use granted on November 14, 2017 covering particle size, density, surface area, drug dissolution, and other aspects. "NanOlogy investigational drugs are being developed under FDA’s streamlined 505(b) 2 pathway" said Michael Baltezor, PhD, head of product development. "Coupled with a composition patent on our particles, we now enjoy NME [new molecular entity] – like IP advantages without the corresponding risk and time associated with NME development."

NanOlogy expects results from its clinical trials in 2018 and during this time will be identifying a pharmaceutical or strategic investment partner to progress its drug candidates to NDA submission, market approval, and commercial distribution.

On January 3, 2018 Siamab Therapeutics, Inc., a biopharmaceutical company developing novel cancer therapeutics, reported that Jeff Behrens, president and chief executive officer, will present at the 10th annual Biotech Showcase conference in San Francisco on Tuesday, January 9, 2018 at 1:45 p.m. PT (Press release, Siamab Therapeutics, JAN 3, 2018, View Source [SID1234522845]). The conference will be held January 8-10, 2018, at the Hilton San Francisco Union Square.

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"We look forward to presenting an overview of our glycan-targeting platform to treat solid tumors"

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Mr. Behrens will provide an overview of the company, its proprietary technology platform and its development pipeline, including the ST1 program. ST1, Siamab’s lead monoclonal antibody (mAb) therapeutic, is in late stage preclinical development formatted as an antibody drug conjugate (ADC) for the treatment of solid tumors expressing Sialyl-Tn (STn). Mr. Behrens will also present new data on targeting STn+ myeloid-derived suppressor cells (MDSCs), major regulators of the tumor anti-immune response that act by suppressing T cells. Siamab has for the first time identified and utilized the presence of STn on MDSCs to target and deplete MDSCs in vivo, providing a potential new therapeutic approach for the treatment of solid tumors.

"We look forward to presenting an overview of our glycan-targeting platform to treat solid tumors," said Mr. Behrens. "We will be focusing on promising new data from the ST1 program that points to STn+ MDSCs as an exciting and untapped immune-oncology target. ST1 has demonstrated excellent efficacy and safety in multiple IND-enabling tumor models as a direct anti-cancer therapy, and it may also have the potential to deplete MDSCs, which are known to be potent suppressors of tumor immunity."

Siamab’s proprietary technology platform enables the development of highly specific mAb therapeutics, including ADCs, bi-specific antibodies and CAR-T cell therapies, targeting cancer cell surface glycans called tumor-associated carbohydrate antigens (TACAs). TACAs are an emerging set of tumor antigens that are implicated in immune suppression, chemoresistance and a cancer stem cell (CSC) phenotype. The elevated presence of STn—a key TACA observed in a number of solid tumors, including ovarian, prostate, pancreatic, gastric, and colon—is associated with metastatic disease, poor prognosis, and reduced overall survival. Elevation of STn expression is linked to chemotherapy resistance and enables tumors to evade the host immune system. In addition, STn is expressed on multiple biomarkers including the CSC biomarkers CD44 and MUC1, which reside on both CSCs and mature malignant cells in some cancer types.

Siamab scientists have demonstrated the safety and efficacy of their anti-STn antibody therapeutic in multiple preclinical studies. The company’s lead ST1 ADC was shown to inhibit tumor progression in cell line-derived and patient-derived xenograft (PDX) mouse models of ovarian and pancreatic cancer, with complete regression observed in some treatment arms. In addition, preclinical evaluation has demonstrated the compound’s safety across species, including in non-human primates.

Siamab is also utilizing STn-selective antibodies to develop both tissue- and serum-based biomarker assays with the potential to become companion diagnostics for both the stratification of patients as well as tools for assessing the pharmacodynamics action of the anti-STn therapeutic in the clinic.