Pacira Pharmaceuticals to Present at the 2018 Barclays Global Healthcare Conference

On march 6, 2018 Pacira Pharmaceuticals, Inc. (NASDAQ:PCRX) reported that the company is scheduled to participate in an analyst-led fireside chat at the 2018 Barclays Global Healthcare Conference at 11:15 AM ET on Tuesday, March 13, 2018 in Miami (Press release, Pacira Pharmaceuticals, MAR 6, 2018, View Source;p=RssLanding&cat=news&id=2336413 [SID1234524459]).

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A live audio webcast of the Pacira presentation can be accessed by visiting the "Investors & Media" section of the company’s website at investor.pacira.com. A replay of the webcast will be archived on the Pacira website for two weeks following the presentation date.

Apexigen and the Pediatric Brain Tumor Consortium Announce a Clinical Collaboration to Evaluate APX005M in Children with Brain Tumors

On March 6, 2018 Apexigen, Inc., a clinical-stage biopharmaceutical company, and the Pediatric Brain Tumor Consortium (PBTC), reported a clinical trial collaboration to evaluate Apexigen’s APX005M, an investigational immune activating compound that targets CD40, in pediatric patients with recurrent or refractory brain tumors (Press release, Apexigen, MAR 6, 2018, View Source [SID1234591002]). CD40 is an immune co-stimulatory receptor essential to the activation of both innate and adaptive immune responses against cancer. There is an unmet need in pediatric oncology for effective treatments for Central Nervous System (CNS) tumors. Immunotherapy is currently considered a promising area of investigation in clinical oncology and it is expected that novel immune-activating agents such as APX005M will provide additional benefit to complement the currently used immune checkpoint inhibitors.

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The PBTC will conduct a Phase 1 dose escalation trial of APX005M in children at its participating academic medical centers and children’s hospitals across the United States. Objectives of the study include establishing the safety, tolerability, pharmacokinetics and preliminary evidence of activity for APX005M in the pediatric population. Ira Dunkel, M.D., Chairman of the PBTC Steering Committee, said, "We believe that CD40 activation is a very promising area of immunotherapy for cancer, and we are happy to be collaborating with Apexigen to evaluate APX005M in our pediatric patients."

"In a Phase 1 study, APX005M has demonstrated immune stimulation in adult patients with solid tumors," said Xiaodong Yang, M.D., Ph.D., President and CEO of Apexigen. "We are excited about the opportunity to collaborate with the PBTC to explore the effects of treatment with APX005M in this underserved pediatric population."

APX005M is a novel, humanized investigational monoclonal antibody designed to overcome the systemic immune suppression that typically affects cancer patients through activation of CD40, a co-stimulatory receptor on the antigen presenting cells that is essential for activating both innate and adaptive immunity.

Tarveda Therapeutics to Present at Upcoming Investor Conferences

On March 6, 2018 Tarveda Therapeutics, Inc., a clinical stage biopharmaceutical company discovering and developing Pentarins as a new class of potent and selective cancer medicines, reported that Drew Fromkin, President and Chief Executive Officer, will present at Cowen’s 38th Annual Health Care Conference, occurring March 12-14, 2018 in Boston, MA and Needham & Company’s 17th Annual Healthcare Conference, occurring March 27-28, 2018 in New York City (Press release, Tarveda Therapeutics, JUN 6, 2018, View Source [SID1234524525]). Tarveda presentation details:

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Cowen and Company 38th Annual Health Care Conference
Date: Tuesday, March 13
Time: 5:00pm Eastern Time
Location: MIT Room, Boston Marriott Copley Place, Boston, MA

Needham & Company’s 17th Annual Healthcare Conference
Date: Tuesday, March 27
Time: 1:30pm Eastern Time
Location: Westin Grand Central Hotel, New York, NY

About Pentarins

Tarveda is developing Pentarins, potent and selective miniature drug conjugates with high affinity for specific cell surface and intracellular targets. Pentarins are engineered to bind to their tumor cell targets and provide sustained release of their potent therapeutic payloads deep into solid tumor tissue. Comprised of a targeting ligand conjugated to a potent cancer cell-killing agent through a tuned chemical linker, Pentarins are designed to overcome the deficits of both larger antibody drug conjugates and small molecules that limit their therapeutic effectiveness against solid tumors. Together, the components of Tarveda’s Pentarins have distinct, yet synergistic, anticancer attributes: the small size of Pentarins allows for rapid and deep penetration into the tumor tissue, the ligand’s targeting ability allows for specific binding and retention in tumor cells, and the chemical linker is tuned to optimize the release of the potent, cell-killing payload inside the cancer cells for efficacy.

Arrowhead to Present at Barclays Global Healthcare Conference 2018

On March 6, 2018 Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) reported that the company will make a presentation at the following upcoming event (Press release, , JUN 6, 2018, View Source [SID1234524624]):

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Barclays Global Healthcare Conference – Miami, March 13, at 1:35 p.m. EDT

A webcast of the event may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website.

10-K – Annual report [Section 13 and 15(d), not S-K Item 405]

PTC Therapeutics has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission (Filing, 10-K, PTC Therapeutics, 2018, MAR 6, 2018, View Source [SID1234524429]).

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