On December 20, 2018 AngioDynamics, Inc. (NASDAQ: ANGO), a leading provider of innovative, minimally invasive medical devices for vascular access, peripheral vascular disease, and oncology, reported that Jim Clemmer, President and Chief Executive Officer, and Michael C. Greiner, Executive Vice President and Chief Financial Officer, will present at the 37th Annual J.P. Morgan Healthcare Conference at 3:00 p.m. PT on Tuesday, January 8, 2019 in San Francisco, CA (Press release, AngioDynamics, DEC 20, 2018, View Source [SID1234532201]).

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A live webcast of the presentation and Q&A breakout session will be accessible through the "Investors" section of the Company’s website at www.angiodynamics.com and will be available for replay following the event.

On December 20, 2018 Exact Sciences Corp. (Nasdaq: EXAS) reported that company management will be presenting at the following investor conference and invited investors to participate by webcast (Press release, Exact Sciences, DEC 20, 2018, View Source [SID1234532218]).

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J.P. Morgan Healthcare Conference presentation, San Francisco
Tuesday, Jan. 8, 2019, at 2:00 p.m. PST
J.P. Morgan Healthcare Conference question & answer session, San Francisco
Tuesday, Jan. 8, 2019, at 2:30 p.m. PST

The webcast can be accessed in the investor relations section of Exact Sciences’ website at www.exactsciences.com.

On December 20, 2018 GT Biopharma, Inc. (OTCQB: GTBP and Euronext Paris GTBP.PA) ("GT Biopharma" or the "Company"), an immuno-oncology biotechnology company focused on innovative treatments based on the Company’s proprietary NK-engager and Bispecific Antibody Drug Conjugate platforms, reported that Raymond W Urbanski, M.D., Ph.D., Chief Executive Officer and Chairman, will present at Biotech Showcase 2019 on Tuesday, January 8, 2019 at 11:30 AM PST in San Francisco, CA (Press release, GT Biopharma , DEC 20, 2018, View Source [SID1234539517]).

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As part of his presentation, Dr. Urbanski will provide a corporate update and discuss GT Biopharma’s pipeline of immuno-oncology products based off the Company’s proprietary Tri-specific Killer Engager (TriKE), Tetra-specific Killer Engager (TetraKE) and bi-specific Antibody Drug Conjugate (ADC) technology platforms.

The Company’s most advanced bi-specific ADC in development, GTB-1550, targets CD19+ and/or CD22+ hematological malignancies and is currently in the Phase 2 component of a Phase 1/2 Non-Hodgkin’s Lymphoma (NHL)/Acute Lymphocytic Leukemia (ALL) trial which is an open-label, investigator-led study. GT Biopharma expects to announce topline results from the Phase 2a trial of GTB-1550 in the first quarter of 2019.

Additionally, the Company recently announced its Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) is now open and it is authorized to initiate a first-in-human Phase 1 study with GTB-3550 (formerly OXS-3550), its first-in-class (TriKE), for the treatment of acute myelogenous leukemia (AML), myelodysplatic syndrome (MDS) and mastocytosis. The study, which is expected to commence in the first half of 2019, will be led by Principal Investigator, Sarah A. Cooley, MD, MS, Associate Professor, Division of Hematology, Oncology and Transplantation at Masonic Cancer Center, University of Minnesota. The Company believes that GTB-3550 could serve as a relatively safe, cost-effective, and easy-to-use therapy for refractory/relapsed AML, high-risk MDS and advanced systemic mastocytosis and could also be combined with chemotherapy and/or other agents as frontline therapy thus targeting a much larger patient population.

In addition to the presentation, Dr. Urbanski will also be available to participate in one-on-one meetings with qualified members of the investor community who are registered to attend the conference. For more information about the conference, please click here to visit the conference website.

A live audio webcast of the presentation will be available on the Events page of the Investors section of the Company’s website (www.gtbiopharma.com). A webcast replay will be accessible for 90 days following the live presentation.

On December 20, 2018 Apexigen, Inc., a clinical-stage biopharmaceutical company, reported a collaboration with Columbia University Irving Medical Center on a new Phase 2 study for its lead immuno-oncology (I-O) therapeutic APX005M, a monoclonal antibody targeting CD40, in combination with doxorubicin and olaratumab in patients with advanced sarcomas (Press release, Apexigen, DEC 20, 2018, View Source [SID1234590999]). The trial is being funded by Apexigen and is being conducted by researchers at Columbia University Irving Medical Center.

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"We are excited to collaborate on this important new study," said Xiaodong Yang, M.D., Ph.D., President and Chief Executive Officer of Apexigen. "We believe that combining APX005M with the standard of care could benefit many cancer patients. In conducting this trial we hope that we may advance better I-O treatment options for patients with sarcomas."

Additional information on this trial can be found on the ClinicalTrials.gov website at: NCT03719430.

About APX005M
APX005M is a novel, humanized monoclonal antibody that stimulates the anti-tumor immune response. APX005M targets CD40, a co-stimulatory receptor that is essential for activating both innate and adaptive immune systems. Binding of APX005M to CD40 on antigen presenting cells (i.e., dendritic cells, monocytes and B-cells) initiates a multi-faceted immune response bringing multiple components of the immune system (e.g., T cells, macrophages) to work in concert against cancer. APX005M is currently in Phase 2 clinical development for the treatment of cancers such as melanoma, non-small cell lung cancer, pancreatic cancer, esophageal and gastroesophageal junction cancers and renal cell carcinoma in various combinations with immunotherapy, chemotherapy or radiation therapy.

On December 20, 2018 Vaccitech, a clinical stage developer of a universal flu vaccine and other vaccine-related products, reported that it has received a joint £6m investment from a Korean biotech company, GeneMatrix, and venture capital and private equity firm, Korea Investment Partners (Press release, Vaccitech, DEC 20, 2018, View Source [SID1234532187]).

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Vaccitech and GeneMatrix also intend to enter into a formal collaborative agreement that will create business synergies between the companies through expansion of advanced vaccine development programs in Korea. GeneMatrix has recently begun internal vaccine development through a Zika virus vaccine program, backed by a government grant from Korea Centres for Disease Control and Prevention. Vaccitech will use the present investment to advance ongoing clinical projects and expand its research and development efforts.

Tom Evans, Chief Executive Officer at Vaccitech, said:

"The GeneMatrix team is experienced in the infectious disease areas, especially in chronic Hepatitis B and Human Papilloma virus, which are a major unmet medical need, and our vaccine programs in such areas will be quite synergistic."

Soo-OK Kim, Chief Executive Officer at GeneMatrix, added:

"We hope the combination of Vaccitech’s T-cell induction platform and GeneMatrix’s molecular and therapeutic platform will lead to better clinical development of advanced vaccines and new therapeutics."

Vaccitech is a spin-out from the University of Oxford and is commercialising decades of viral vector vaccine research conducted at the University’s Jenner Institute. The company’s proprietary T-cell induction platform comprises non-replicating viral vectors that induce some of the most potent cell-mediated immune responses reported in humans against target pathogens and cancer. Vaccitech has multiple vaccine and therapeutic products targeting indications across infectious diseases and oncology.