Thermo Fisher Scientific to Present at the Jefferies 2018 London Healthcare Conference on November 14, 2018

On October 31, 2018 Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, reported that Marc N. Casper, president and chief executive officer, will present at the Jefferies 2018 London Healthcare Conference on Wednesday, November 14, 2018, at 10:40 a.m. (GMT) at the Waldorf Hilton, London, UK (Press release, Thermo Fisher Scientific, OCT 31, 2018, View Source [SID1234530460]).

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You can access the live webcast of the presentation in the Investors section of our website, www.thermofisher.com.

Affimed Announces Third Quarter 2018 Financial Results and Corporate Update Conference Call on November 7, 2018

On October 31, 2018 Affimed N.V. (Nasdaq: AFMD), a clinical stage biopharmaceutical company focused on discovering and developing highly targeted cancer immunotherapies, reported that it will host a conference call on Wednesday, November 7, 2018 at 8:30 a.m. ET to discuss its third quarter financial results and recent corporate developments (Press release, Affimed, OCT 31, 2018, View Source [SID1234530417]).

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The conference call will be available via phone and webcast. To access the call, please dial (323) 794-2588 for U.S. callers, or +44 (0)330 336 9125 for international callers, and reference conference ID 6650897 approximately 15 minutes prior to the call.

An audio webcast of the conference call can be accessed in the "Events" section on the "Investors & Media" page of the Affimed website at View Source A replay of the webcast will be available on Affimed’s website shortly after the conclusion of the call and will be archived on the Affimed website for 30 days following the call

Apricus Biosciences Provides Corporate Update and Third Quarter 2018 Financial Results

On October 31, 2018 Apricus Biosciences, Inc. (Nasdaq:APRI), a biopharmaceutical company historically focused on seeking to advance innovative medicines in urology and rheumatology, reported financial results for the third quarter and year-to-date for 2018 and provided a corporate update on its pending merger with Seelos Therapeutics, Inc (Press release, Apricus Biosciences, OCT 31, 2018, View Source;p=RssLanding&cat=news&id=2374547 [SID1234530461]).

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On July 30, 2018, the Company announced the signing of a definitive agreement to merge with Seelos Therapeutics, Inc., a privately-held biotechnology company, in an all-stock transaction. The merged company will focus on the development and commercialization of central nervous system (CNS) therapeutics with known mechanisms of action in areas with a highly unmet medical need. Upon completion of the proposed merger, the name of the merged company will be Seelos Therapeutics, Inc., and the company is expected to begin trading on the Nasdaq Capital Market under the ticker symbol "SEEL." Upon closing of the transaction, Apricus shareholders of record are expected to own approximately 15% of the combined company based on an estimated $94 million valuation at closing, subject to certain adjustments set forth in the merger agreement. In addition, Apricus shareholders of record at closing will receive a Contingent Value Right (CVR) which will provide such holders 90% of any proceeds above $500,000 obtained by Seelos for the U.S. Vitaros rights.

"Throughout the third quarter of this year, we have been focused on a concluding the proposed merger with Seelos, as our board believes it will provide Apricus shareholders an opportunity to create value from a funded, diversified pipeline of late-stage clinical assets in areas of high unmet need," said Richard Pascoe, Chief Executive Officer. "We will continue to work with Seelos management in the coming weeks to complete the merger following the Special Stockholder Meeting."

Third Quarter and Year-to-Date Financial Results

Net loss during the quarter ended September 30, 2018 was $2.8 million, or loss per share of $0.12, compared to a net loss of $3.8 million, or loss per share of $0.29, during the third quarter of 2017. Net loss during the nine months ended September 30, 2018 was $7.4 million, or loss per share of $0.35, compared to net income of $2.8 million, or earnings per share of $0.26, during the nine months ended September 30, 2017. Net income during the nine months ended September 2017 was primarily due to the $11.8 million gain recorded upon the sale of our ex-U.S. Vitaros rights and assets to Ferring.

For all periods presented, financial statement activity related to our ex-U.S. Vitaros business has been presented as discontinued operations. As of September 30, 2018, the Company’s cash totaled $5.3 million, compared to $6.3 million as of December 31, 2017.

Mustang Bio Announces Updates on CAR T Cell Therapy Clinical Trials with City of Hope

On October 30, 2018 Mustang Bio, Inc. ("Mustang") (NASDAQ: MBIO), a company focused on the development of novel immunotherapies based on proprietary chimeric antigen receptor engineered T cell (CAR T) technology and gene therapies for rare diseases, reported that a Phase 1 clinical trial evaluating the safety and effectiveness of intraventricular delivery of CAR T cells to the brains of patients with HER2-positive breast cancer with brain metastases has been initiated (Press release, Mustang Bio, OCT 30, 2018, View Source [SID1234530379]).

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The trial, which is being conducted by City of Hope, a world-renowned independent cancer research and treatment center, is expected to enroll 21 patients, many of whom are likely to be women with HER2-positive breast cancer. According to the American Cancer Society, about 1 in 5 patients with breast cancer have HER2- positive cancer cells. Nearly half of patients with HER2-positive breast cancer develop brain metastases.

Manuel Litchman, M.D., President and Chief Executive Officer of Mustang, said, "We are pleased that this innovative clinical trial, which is the first to deliver HER2-specific CAR T cell therapy directly to the brains of patients whose breast cancer has metastasized to the brain, is now underway. There are currently few treatments available for these patients, and we are hopeful that our CAR T cell therapy will offer a safe and effective option to treat this terrible disease."

The trial’s primary objective is to determine the safety and recommended Phase 2 dosing of intraventricular delivery of HER2-specific CAR T cells. Secondary objectives include assessing cerebrospinal fluid (CSF) and peripheral blood for HER2-CAR T cell persistence and endogenous immune system activation, describing changes in cytokine levels in the CSF and peripheral blood and describing changes in circulating tumor cells in the CSF.

In addition, Mustang has announced that City of Hope has dosed the first patient in a Phase 1 clinical trial of HER2-specific CAR T cells in treating recurrent or refractory grade III-IV glioma. The trial will evaluate the side effects and best dose of HER2-specific CAR T cells in treating patients with grade III-IV glioma that has come back or does not respond to treatment. Dr. Litchman added, "The advancement of these clinical trials marks an exciting time for Mustang. We look forward to learning more about how we can better treat patients with HER2-positive brain metastases or gliomas."

Synthetic Biologics to Report Third Quarter 2018 Operational Highlights and Financial Results on November 8, 2018

On October 30, 2018 Synthetic Biologics, Inc. (NYSE American: SYN), a late-stage clinical company developing therapeutics that preserve the microbiome to protect and restore the health of patients, reported that the Company intends to release its operational highlights and financial results for the quarter ended September 30, 2018 on Thursday, November 8, 2018, and to host a conference call the same day at 4:30 p.m. EDT (Press release, Synthetic Biologics, OCT 30, 2018, View Source [SID1234530418]). The dial-in information for the call is as follows:

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U.S. (toll free): 1-888-347-5280
International: +1 412-902-4280

Participants are asked to dial in 15 minutes before the start of the call to register. The call will also be webcast over the Internet at View Source." target="_blank" title="View Source." rel="nofollow">View Source An archived replay of the call will be available for approximately ninety (90) days at the same URL, View Source beginning approximately one hour after the call’s conclusion.