On March 14, 2018 NewLink Genetics Corporation (NASDAQ: NLNK) reported that two abstracts pertaining to the company’s indoximod program will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2018 Annual Meeting in Chicago (Press release, NewLink Genetics, MAR 14, 2018, View Source [SID1234524773]).
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Clinical Trials Plenary Session: Abstract 10973 – Front-line therapy of DIPG using the IDO pathway inhibitor indoximod in combination with radiation and chemotherapy, to be presented during the "Multimodality Immuno-oncology Approaches" session, Sunday, April 15, 2018, 12:45 PM – 2:45 PM CT
Poster Session: Abstract 3753 – Indoximod modulates AhR-driven transcription of genes that control immune function, to be presented during poster session PO.IM02.07, April 17, 2018, 8:00 AM – 12:00 PM CT
The complete text of Clinical Plenary Session abstracts that have not been selected for the press program will be posted to the AACR (Free AACR Whitepaper) website on Friday, April 13. The text of clinical trials abstracts that have been selected for inclusion in the press program will not be posted online until the date and time of presentation.
"We are pleased to have been chosen to present these abstracts at the upcoming AACR (Free AACR Whitepaper) meeting," said Charles J. Link, Jr, MD, Chairman, CEO and Chief Scientific Officer. "Encouraging early clinical data of indoximod plus radiation for pediatric patients with DIPG, a rare and lethal form of brain cancer, will be presented. In addition, our data further clarifying indoximod’s differentiated mechanism of action will also be presented."
About Indoximod
Indoximod is an investigational, orally available small molecule targeting the IDO pathway. The IDO pathway is a key immuno-oncology target involved in regulating the tumor microenvironment and immune escape. Indoximod is being evaluated in combination with treatment regimens including anti-PD-1/PD-L1 agents, cancer vaccines, and chemotherapy across multiple indications such as melanoma, pancreatic cancer and other malignancies.