On April 11, 2018 Tarveda Therapeutics, Inc., a clinical stage biopharmaceutical company discovering and developing Pentarins as a new class of potent and selective cancer medicines, reported that the company will present preclinical data related to PEN-866 at the 2018 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, occurring April 14-18, 2018 in Chicago, IL (Press release, Tarveda Therapeutics,APR 11, 2018, View Source [SID1234525272]). PEN-866 is a miniature drug conjugate designed to treat patients with solid tumor types known to be sensitive to topoisomerase 1 inhibitors such as SN-38, the payload of PEN-866. The presentation will address the combination of PEN-866 with PARP inhibitors in models of ovarian cancer, lung cancer and colorectal cancer.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details of the poster presentation are as follows:

Title: Combination of the miniature drug conjugate PEN-866 with PARP inhibitors as a rational approach to overcoming limitations of PARP inhibitor monotherapy
Date:

April 18, 2018
Time:

8:00 AM – 12:00 PM CT
Location:

Section 37, McCormick Place North/South, Chicago, IL

About PEN-866
PEN-866 exploits the activation of Heat Shock Protein 90 (HSP90) in tumors to accumulate and release its potent anti-cancer payload, SN-38. PEN-866 is a miniature conjugate that comprises a small molecule, HSP90-targeting ligand linked to SN-38, the active metabolite of irinotecan. The conjugate accumulates and is retained in tumors, and by way of a sustained release of SN-38, causes prolonged DNA damage and tumor regressions in multiple patient-derived and other xenograft tumor models.

About Pentarins
Tarveda is developing Pentarins, potent and selective miniature drug conjugates with high affinity for specific cell surface and intracellular targets. Pentarins are engineered to bind to their tumor cell targets and provide sustained release of their potent therapeutic payloads deep into solid tumor tissue. Comprised of a targeting ligand conjugated to a potent cancer cell killing agent through a tuned chemical linker, Pentarins are designed to overcome the deficits of both larger antibody drug conjugates and small molecules that limit their therapeutic effectiveness against solid tumors. Together, the components of Tarveda’s Pentarins have distinct, yet synergistic, anticancer attributes: the small size of Pentarins allows for rapid and deep penetration into the tumor tissue, the ligand’s targeting ability allows for specific binding and retention in tumor cells, and the chemical linker is tuned to optimize the release of the potent, cell killing payload inside the cancer cells for efficacy.

On April 11, 2018 Percans Oncology reported that it has developed i-CR, a personalized drug susceptibility testing platform for the precise treatment of colon cancer, to provide clinicians and patients with the most valuable medical plan for reference (Press release, Cothera Bioscience, APR 11, 2018, View Source [SID1234618854]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Features of i-CR in vitro drug susceptibility testing platform

i-CR drug susceptibility testing technology focuses on the functionality of tumor cells. It investigates the response of tumor cells under the action of drugs instead of exploring the relationship between drug susceptibility and changes in genes and proteins. The i-CR results are more practical and correspondence to clinical outcomes. This technology takes small samples of patients’ tumors, and performs rapid and high-throughput, drug susceptibility tests for drugs that have been marketed or entered clinical trials, thus providing a strong basis for clinicians to make optmized medical plans for each individual patient.

Target Patients

l Patients newly diagnosed as stage III or IV colorectal cancer;

l Patients who have failed the standard first-line treatment plan and hope to choose the best plan;

l Patients who have local or distant metastases and cannot benefit from genetic testing;

l Patients who are resistant to targeted drugs and need to find effective multiple targeted drugs and targeted combinations.

On April 10, 2018 Asana BioSciences, LLC, an oncology focused, clinical stage biopharmaceutical company, reported that it will present updates for two of its lead molecules in clinical development at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting being held in Chicago, IL, April 14-18, 2018 (Press release, Asana BioSciences, APR 10, 2018, View Source [SID1234525253]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The presentation details are as follows:

1. ASN003, a novel highly selective BRAF and PI3K dual inhibitor: Phase I PK/PD results in patients with advanced solid tumors.

Authors: D. Rasco1, N. Lakhani2, R. Sullivan3, M. Mita4, J. Shah5, H. Usansky5, S. Reddy5, N. S. Rao5, L. Denis5, K. Flaherty3, Anthony Tolcher6. 1START Med. Oncology, San Antonio, TX; 2START Med. Oncology, Grand Rapids, MI; 3MGH, Boston, MA; 4Cedars Sinai Med. Oncology, Los Angeles, CA; 5Asana BioSciences, Lawrenceville, NJ, 6NEXT Oncology, San Antonio, TX.
Session: PO.CT01 – Phase I Clinical Trials 1; Section 42
Abstract: #CT019 / 12
Date/Time: Sunday, April 15 at 1:00pm – 5:00pm

2. Strong antitumor activity of ASN007, an oral ERK1/2 inhibitor, in PDX tumor models with MAP kinase pathway alterations including KRAS mutations.

Authors: Sanjeeva P. Reddy, Niranjan S. Rao, Roger A. Smith, Scott K. Thompson, Sarper
Toker. Asana BioSciences, Lawrenceville, NJ.
Session: PO.ET06.10 – Canonical Targets 2; Section 36
Abstract: #5783 / 9
Date/Time: Wednesday, April 18 at 8:00am – 12:00pm

ASN003 is a potent and highly selective inhibitor of both B-RAF and PI3 kinases. RAS-RAF-MEK and PI3K-AKT-mTOR are two major pathways involved in tumor cell signaling and growth. Components of these pathways are frequently mutated in a broad range of tumors. Selective BRAF inhibitors induce dimerization of RAF proteins, leading to paradoxical activation of the RAF-MEK-ERK cascade. This activation is a major limitation for the clinical use of selective RAF inhibitors, as it leads to resistance and results in side effects in the skin limiting their use in patients with BRAF mutant tumors. In addition, elevated signaling through the PI3K/AKT pathway, with or without concomitant MAPK reactivation, represents an alternative path to resistance to BRAF inhibitors. ASN003 demonstrates broad anti-proliferative activity in tumor cell lines and strong tumor growth inhibition in tumor xenograft models, including BRAF inhibitor resistant models. ASN003 is currently in Phase I clinical development in patients with advanced solid tumors, including melanoma, colorectal cancer and non-small cell lung cancer (clinicaltrials.gov NCT02961283). ASN003 is well tolerated and shows the potential to be developed as a monotherapy or in combination with checkpoint inhibitors or other standard of care.

ASN007 is a potent inhibitor of the extracellular-signal-regulated kinases, ERK1 and ERK2 (ERK1/2), key players in the RAS/RAF/MEK (MAPK) signaling pathway. This pathway is frequently hyper-activated in a wide range of cancers through mutations in upstream targets such as BRAF and RAS proteins. Inhibition of ERK1/2 offers a promising therapeutic strategy for such cancers. ASN007 shows potent and selective anti-proliferative activity in cancer cell lines that are driven by the MAPK-pathway, including RAS mutant cell lines. Furthermore, ASN007 demonstrates strong inhibition of tumor growth in multiple BRAF and KRAS mutant patient-derived and cell-line-derived xenograft models, including those that are resistant to BRAF and MEK inhibitors. ASN007 is currently in Phase I clinical development in patients with advanced solid tumors, including melanoma, colorectal cancer, non-small cell lung cancer and pancreatic cancer (clinicaltrials.gov NCT03415126).

On April 10, 2018 harles River Laboratories International, Inc. (NYSE: CRL) reported that its team of oncology experts is presenting 13 scientific posters, both independently and collaboratively with clients, and will highlight an enhanced oncology portfolio at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (Press release, Charles River Laboratories, APR 10, 2018, View Source [SID1234525254]). The meeting is taking place from April 14-18, 2018, at McCormick Place in Chicago, Illinois.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Throughout the meeting, Charles River’s experts will present the Company’s industry-leading oncology capabilities and highlight the latest advancements by presenting innovative applications for CRISPR/Cas9, immuno-oncology, in vitro assays, and more.

Noteworthy posters include:

Determination of signal transduction pathway activity in patient-derived xenograft models in comparison with clinical patient tumor samples for a variety of human cancer types (Presented: Monday, April 16, 8:00 a.m.-12:00 p.m.) This project, completed with Philips Molecular Pathway Diagnostics, describes an analysis method which identifies and quantifies activity in the cell signaling pathways of Charles River’s patient-derived xenograft (PDX) tumor models.
A translational platform using primary human immune cells in vitro, syngeneic and humanized models in vivo to support and advance immuno-oncology drug discovery (Presented: Monday, April 16, 8:00 a.m.-12:00 p.m.) Researchers established a translational immuno-oncology platform with the capability of progressing biologics or small-molecule modulators of immune response from in vitro and ex vivo through in vivo assays, including humanized models.
Quantitative measurement of immune-modulatory mediators within tumors of freely moving mice utilizing in vivo microdialysis (Presented: Tuesday, April 17, 8:00 a.m.-12:00 p.m.) Leveraging microdialysis in tumors, researchers monitored changes in biochemical elements within tumors to better understand cancer biology in the development of novel therapies.
A full schedule of Charles River’s activities during AACR (Free AACR Whitepaper) 2018 is available online. Reprints of each poster will be available in Booth #1615 during the conference and Charles River experts will be available for meetings to discuss how an integrated approach can support drug discovery and development programs from hit ID to IND. Throughout the conference, Charles River will be providing live updates on the Eureka Blog, including reviews of scientific sessions and input on the research being presented.

Bioinformatic Additions to Compendium

In February 2018, Charles River announced the launch of its new online Tumor Model Compendium web interface. The new Compendium interface provides oncology researchers with an easily accessible, user-friendly resource to identify tumor models based on specific molecular and histological properties, accompanied by selected patient information. Ahead of AACR (Free AACR Whitepaper), Charles River will incorporate the signal transduction pathway activity, developed with Philips Molecular Pathway Diagnostics, as a characteristic of Charles River’s PDX models. The resemblance of these pathways to clinical samples will lead to better development and clinical application of targeted drugs for personalized cancer treatment.

Select Humanization Kit

Recently, Charles River and HemaCare Corporation (OTCBB: HEMA) formed a strategic partnership to advance human immune system research by developing a more efficient and reliable method of working with humanized mice. Through the partnership, HemaCare’s peripheral blood mononuclear cells (PBMCs) are paired with Charles River’s NCG triple immunodeficient mouse. This NCG/PBMC Select Humanization Kit is the first of its kind in the industry and provides both the NCG mouse and vials of prescreened human PBMCs, allowing researchers to efficiently develop humanized mouse models on their own timeline.

Approved Quotes

"Our scientists are exploring groundbreaking applications of innovative tools and technologies across oncology research. From CRISPR to in vitro immuno-oncology to microdialysis, our deep scientific bench affords us a unique opportunity to leverage learnings from different therapeutic areas and apply them to oncology. We’re proud to showcase our body of work at AACR (Free AACR Whitepaper) this year." –Birgit Girshick, Corporate Executive Vice President, Discovery and Safety Assessment, Charles River
"The continued expansion of our Tumor Model Compendium highlights the significant role bioinformatics plays in oncology research. Scientists require data to conduct their research efficiently and effectively. Our Compendium puts the power of our data in their hands—eliminating steps and driving the development process forward." –Aidan Synnott, Executive Director, Discovery Oncology, Charles River
About the American Association for Cancer Research (AACR) (Free AACR Whitepaper)

The mission of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) is to prevent and cure cancer through research, education, communication, and collaboration. Through its programs and services, the AACR (Free AACR Whitepaper) fosters research in cancer and related biomedical science; accelerates the dissemination of new research findings among scientists and others dedicated to the conquest of cancer; promotes science education and training; and advances the understanding of cancer etiology, prevention, diagnosis, and treatment throughout the world.

On April 10, 2018 AngioDynamics, Inc. (NASDAQ: ANGO), a leading provider of innovative, minimally invasive medical devices for vascular access, peripheral vascular disease, surgery and oncology, reported that it will present at the following two investor conferences in May (Press release, AngioDynamics, APR 10, 2018, View Source [SID1234525255]):

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Conference: Deutsche Bank 43rd Annual Healthcare Conference
Location: Boston, MA
Date: Tuesday, May 8, 2018
Presentation: 3:30 p.m. ET
Speakers: Jim Clemmer, President and Chief Executive Officer, and Michael C. Greiner, Executive Vice President and Chief Financial Officer

Conference: UBS Global Healthcare Conference
Location: New York, NY
Date: Monday, May 21, 2018
Presentation: 9:00 a.m. ET
Speaker: Jim Clemmer, President and Chief Executive Officer

A live webcast of each presentation will be accessible through the "Investors" section of the Company’s website at www.angiodynamics.com and will be available for replay following each event.