On January 24, 2019 Anixa Biosciences, Inc. (NASDAQ: ANIX), a biotechnology company focused on using the body’s immune system to fight cancer, reported that the U.S. Patent and Trademark Office has issued a Notice of Allowance for the first patent covering Anixa subsidiary, Certainty Therapeutics, Inc.’s, CAR-T cancer treatment technology (Press release, Anixa Biosciences, JAN 24, 2019, View Source [SID1234532897]).

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The patent is titled "METHODS AND COMPOSITIONS FOR TREATING CANCER," and the inventors are Drs. Jose Conejo-Garcia and Alfredo Perales-Puchalt. Dr. Conejo-Garcia is the Chair of the Department of Immunology at Moffitt Cancer Center and Dr. Alfredo Perales-Puchalt is a Senior Postdoctoral Fellow in The Wistar Institute’s Vaccine & Immunotherapy Center. The patent is assigned to The Wistar Institute and Anixa Biosciences’ majority-owned subsidiary, Certainty Therapeutics, Inc. is the exclusive, world-wide licensee.

Dr. Amit Kumar, President and CEO of Anixa Biosciences, stated, "This is a ground-breaking patent protecting our CAR-T cancer technology. This technology takes advantage of specific hormone–hormone receptor biology to address malignancies and may hold promise to be the first successful CAR-T therapy against solid tumors. While our initial focus is the treatment of ovarian cancer, the technology covered by the patent is broad and may also be effective in treating other solid tumors by exploiting an anti-angiogenesis mechanism of action."

Dr. Kumar continued, "We are pleased that our licensor and shareholder in Certainty Therapeutics, Inc., The Wistar Institute, has received this Notice of Allowance, as this patent will offer intellectual property protection for the commercialization of this CAR-T solid tumor therapy. We have other filings at various stages of prosecution, and we hope to be receiving additional patents."

"We take seriously our collaborative efforts in protecting intellectual property that is critical for the advancement of new therapies, such as Anixa’s CAR-T therapy," said Heather Steinman, PhD, MBA, Vice President of Business Development at The Wistar Institute. "We are fully aligned with Anixa to ensure that Wistar’s technology may one day be used to help cancer patients."

On January 24, 2019 Incyte Corporation (Nasdaq:INCY) reported that it has scheduled its fourth quarter and year-end 2018 financial results conference call and webcast for 8:00 a.m. ET on Thursday, February 14, 2019 (Press release, Incyte, JAN 24, 2019, View Source [SID1234532881]).

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The schedule for the press release and conference call/webcast is as follows:

Q4 & YE 2018 Press Release:
February 14, 2019 at 7:00 a.m. ET
Q4 & YE 2018 Conference Call:
February 14, 2019 at 8:00 a.m. ET
Domestic Dial-In Number:
877-407-3042

International Dial-In Number:
201-389-0864

Conference ID Number:
13686537

If you are unable to participate, a replay of the conference call will be available for thirty days. The replay dial-in number for the U.S. is 877-660-6853 and the dial-in number for international callers is +1-201-612-7415. To access the replay you will need the conference ID number 13686537.

The live webcast with slides can be accessed at www.incyte.com under For Investors, Events and Presentations and will be available for replay for 30 days

On January 24, 2019 Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) reported that it will host a webcast and conference call on February 7, 2019, at 4:30 p.m. EST to discuss its financial results for the fiscal 2019 first quarter ended December 31, 2018 (Press release, Arrowhead Pharmaceuticals, JAN 24, 2019, View Source [SID1234532898]).

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Conference Call and Webcast Details

Investors may access a live audio webcast on the Company’s website at View Source For analysts that wish to participate in the conference call, please dial 855-215-6159 or 315-625-6887 and provide Conference ID 3194897.

A replay of the webcast will be available on the company’s website approximately two hours after the conclusion of the call and will remain available for 90 days. An audio replay will also be available approximately two hours after the conclusion of the call and will be available for 3 days. To access the audio replay, dial 855-859-2056 or 404-537-3406 and provide Conference ID 3194897.

On January 24, 2019 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported that the first mesothelioma patient has been enrolled and dosed in the Phase I study of CA-170 (Press release, Curis, JAN 24, 2019, View Source [SID1234532882]). CA-170 is an orally available, dual inhibitor of VISTA and PDL1, which the company believes could provide benefit in tumors with high levels of VISTA expression. Over 90% of mesothelioma cells express VISTA.

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The company had previously announced its expectation to begin enrollment of mesothelioma patients in a dedicated cohort within the existing Phase 1 study.

"We are pleased to announce that the CA-170 study has begun dosing patients ahead of schedule," said James Dentzer, President & CEO of Curis. "On last quarter’s earnings call, we outlined the reorganization of company resources to strengthen focus on clinical execution. Today’s announcement is a result of those efforts. We re-iterate our confidence in our expectation to report initial efficacy data in this study in the second half of 2019."

CA-170 is the only anti-VISTA therapeutic currently being studied in a clinical trial. CA-170 has demonstrated favorable safety and tolerability, as well as preliminary anti-tumor activity in patients across multiple tumor types. The Phase I study is the first clinical trial of CA-170 to specifically target a patient population characterized by high levels of VISTA expression.

About the Study
The Phase I, open-label, dose escalation and dose expansion trial evaluating the safety, pharmacokinetics, pharmacodynamics, and clinical effects of orally administered CA-170 in patients with advanced tumors and lymphomas. The dedicated mesothelioma cohort will evaluate CA-170 at two dose levels.

About VISTA
VISTA (V-domain Ig-containing Suppressor of T cell Activation) is an independent, inhibitory T cell checkpoint protein that is expressed on both immune cells and tumor cells. VISTA has been identified as a potential resistance mechanism to treatment with anti-PD1 antibodies in melanoma and anti-CTLA4 antibodies in prostate cancer. Recent literature indicates that high levels of VISTA expression have been found on various tumors, including mesothelioma, ovarian cancer, endometrial cancer, triple negative breast cancer, gastric cancer, and non-small cell lung cancer.

On January 24, 2019 ImmunoGen, Inc., (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that the Company will host a conference call at 8:00 a.m. ET on Friday, February 8, 2019 to discuss its 2018 operating results. Management will also provide a brief update on the business (Press release, ImmunoGen, JAN 24, 2019, View Source [SID1234532883]).

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Conference Call Information
To access the live call by phone, dial 323-794-2093; the conference ID is 6271602. The call may also be accessed through the Investors section of the Company’s website, www.immunogen.com. Following the webcast, a replay of the call will be available at the same location through February 22, 2019.