On March 13, 2018 Pfenex Inc. (NYSE AMERICAN: PFNX), reported that the company will present at Oppenheimer’s 28th Annual Healthcare Conference in New York City (Press release, Pfenex, MAR 13, 2018, View Source2018-03-13-Pfenex-Inc-to-Present-at-Oppenheimers-28th-Annual-Healthcare-Conference" target="_blank" title="View Source2018-03-13-Pfenex-Inc-to-Present-at-Oppenheimers-28th-Annual-Healthcare-Conference" rel="nofollow">View Source [SID1234524737]).

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President and Chief Executive Officer, Eef Schimmelpennink, is scheduled to present on Tuesday, March 20, 2018 from 4:30 PM – 5:00 PM ET in the Track 2 room.

Interested parties can access the live audio webcast for this presentation from the Investors Section of Pfenex’s website at www.pfenex.com. The webcast replay will be available after the conclusion of the live presentation for approximately 60 days.

Pfenex investors and others should note that we announce material information to the public about the Company through a variety of means, including our website (View Source), our investor relations website (View Source), press releases, SEC filings, public conference calls, corporate Twitter account (View Source), Facebook page (View Source), and LinkedIn page (View Source) in order to achieve broad, non-exclusionary distribution of information to the public and to comply with our disclosure obligations under Regulation FD. We encourage our investors and others to monitor and review the information we make public in these locations as such information could be deemed to be material information. Please note that this list may be updated from time to time.

On 13 March, 2018 Boehringer Ingelheim and Vanderbilt University reported the expansion of their successful existing collaboration to develop novel anti-cancer compounds (Press release, Boehringer Ingelheim, MAR 13, 2018, View Source [SID1234524727]).

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The expanded research partnership will focus on the discovery and development of new chemical therapeutics targeting the pro-survival protein MCL1 as a potential therapy against MCL1 dependent cancers. This is the third collaboration between Boehringer Ingelheim and Vanderbilt University to pursue discoveries made in the laboratory of Stephen W. Fesik, Ph.D., at Vanderbilt University School of Medicine.

"Boehringer Ingelheim and Vanderbilt University have the expertise and are jointly focused on discovering breakthrough medicines against the cancer causing proteins KRAS, SOS and now, MCL1," said Darryl McConnell, Ph.D., Vice President and Research Site Head, Boehringer Ingelheim, Austria. "Together, we are committed to driving scientific research and development forward to help patients win the fight against cancer."

"MCL1 is one of the top ten overexpressed genes in human cancer where it plays a role as a survival factor," said Lawrence J. Marnett, Ph.D., Dean of Basic Sciences in the Vanderbilt University School of Medicine.

"It is a great target for therapy but candidate drugs need to disrupt high affinity protein-protein interactions, which is very challenging," Marnett said. "The Fesik laboratory has made impressive strides in developing such compounds and it is exciting to see them advanced toward clinical development through the partnership with Boehringer Ingelheim."

MCL1, when overexpressed, can prevent cancer cells from undergoing programmed cell death (also known as apoptosis). This necessitates the discovery of a molecule that binds extremely tightly and selectively to MCL1 in order to sufficiently induce on-target, mechanism-based cancer cell death.

"Boehringer Ingelheim has an outstanding oncology drug discovery infrastructure that brings various research and development groups together to tackle challenging cancer targets," said Fesik, Professor of Biochemistry, Pharmacology, and Chemistry at Vanderbilt. "In combination with our multidisciplinary team of structural biologists, medicinal chemists and cell biologists, we will work to search for anti-cancer compounds that inhibit MCL1 in order to tackle this complex area of unmet medical need."

Boehringer Ingelheim is steadfast in its partnership with Vanderbilt University and is deeply committed to delivering breakthrough, first-in-class treatments to help cancer patients everywhere, despite the challenges that may present themselves. This agreement between Boehringer Ingelheim and Vanderbilt University includes undisclosed upfront and milestone payments, with the ambition of delivering a new cancer drug to market as quickly as possible.

About Boehringer Ingelheim in Oncology
Cancer takes. Takes away loved ones, time and untapped potential. At Boehringer Ingelheim we are providing new hope for patients by taking cancer on. We are collaborating with the oncology community to deliver scientific breakthroughs to transform the lives of patients. Our primary focus is in lung and gastrointestinal cancers, with the goal of delivering breakthrough, first-in-class treatments that can help win the fight against cancer. Our commitment to innovation has resulted in pioneering treatments for lung cancer and we are advancing a unique pipeline of cancer cell directed agents, immune oncology therapies and intelligent combination approaches to help combat many cancers.

On March 13, 2018 – Checkpoint Therapeutics, Inc. ("Checkpoint") (NASDAQ: CKPT), a
clinical-stage, immuno-oncology biopharmaceutical company focused on the acquisition, development
and commercialization of novel treatments for patients with solid tumor cancers, reported that
James F. Oliviero, President and Chief Executive Officer, will participate in two investor conferences in
March (Press release, Checkpoint Therapeutics, MAR 13, 2018, View Source [SID1234525086]).

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• Oppenheimer’s 28th Annual Healthcare Conference: Checkpoint will host one-on-one meetings
on Wednesday, March 21, 2018, at the Westin New York Grand Central in New York City
• The Wall Street Investor Forum 26th Annual Growth Conference: Checkpoint will present a
company overview on Thursday, March 22, 2018, at 11:50 a.m. EDT at The University Club of New
York in New York City

A live webcast of The Wall Street Investor Forum presentation will be available on the Events page of the
Investors & Media section of Checkpoint’s website: www.checkpointtx.com. An archived replay of the
webcast will be available for approximately 30 days following the presentation.

Verastem has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission (Filing, 10-K, Verastem, 2018, MAR 13, 2018, View Source [SID1234524710]).

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On March 13, 2018 GT Biopharma Inc. (OTCQB: GTBP) (Euronext Paris: GTBP.PA) reported that Shawn Cross, Chairman and Chief Executive Officer, and Raymond Urbanski, Chief Medical Officer, will present a company overview at the Roth Capital Partners 30th Annual Conference on Tuesday, March 13, at 11:30 a.m. PT (Press release, GT Biopharma , MAR 13, 2018, View Source [SID1234539532]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live audio webcast of the event will be available via the ‘Investor Relations’ page of the GT Biopharma website, View Source Please log on through GT Biopharma’s website approximately 10 minutes before the scheduled start time. A replay of the webcast will be archived on Gt Biopharma’s website for 90 days following the call.