On October 31, 2018 Epigenomics AG (FSE: ECX, OTCQX: EPGNY) reported the Veterans Administration New York Harbor Healthcare System (VA-Manhattan) is commencing a study to assess the adherence impact of offering a blood-based colorectal cancer screening test and colonoscopy completion in patients who have refused colonoscopy and fecal immunochemical test (FIT) (Press release, Epigenomics, OCT 31, 2018, View Source [SID1234530405]).

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The VA-Manhattan has received grants from the American Society for Gastrointestinal Endoscopy (ASGE) and New York Society for Gastrointestinal Endoscopy (NYSGE) to assist in the performance of this study. The study will be managed through The Narrows Institute. Epigenomics will provide testing and budgetary support for testing.

Colorectal cancer (CRC) is the fourth most common cancer and the second deadliest cancer in the US. However, CRC is a preventable condition with screening being one of the most impactful public health contributions to prevention. Screening rates are suboptimal due to patient barriers to colonoscopy or stool-based testing. Unscreened patients contribute to approximately 43% of new CRC cases, 70% of CRC deaths, and 76% of CRC treatment expenditures.

The goal of the VA-Manhattan study is to assess the potential of a blood-based test as an acceptable alternative for these screen-resistant individuals. If the proposed study shows high acceptance of the blood test as well as reliable colonoscopy follow up for positive tests, then the blood test could play an important adjunctive role in improving overall screening rates.

"Some people simply don’t want colonoscopy or stool-based colorectal cancer screening, so we need to understand how effective alternative methods such as a blood-based test are at engaging these individuals," said Dr. Peter Liang, the study principal investigator and a gastroenterologist at the VA-Manhattan.

"Unscreened patients contribute significantly to new CRC cases, deaths, and treatment costs," said Greg Hamilton, CEO of Epigenomics AG. "Addressing the unscreened challenge with a blood test could unquestionably have an impact to colorectal cancer management. We look forward to the study outcomes as they have the potential to support the use of a blood test on screening-resistant patients."

On October 31, 2018 Aeterna Zentaris Inc. (NASDAQ:AEZS) (TSX: AEZS) reported that it will announce its third quarter 2018 financial and operating results after market close on Tuesday, November 6, 2018 (Press release, AEterna Zentaris, OCT 31, 2018, View Source [SID1234530472]). The Company will host a conference call to discuss these results on Wednesday, November 7, 2018 at 8:30 a.m. Eastern Time.

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Participants may access the conference call by telephone using the following numbers:

Toll-Free: 877-407-8029, Confirmation #13684540
Toll: 201-689-8029, Confirmation # 13684540
A replay will also be available on the Company’s website for a period of 30 days.

On October 30, 2018 Genomic Health, Inc. (NASDAQ: GHDX) reported that the company will host a conference call and webcast on Tuesday, November 6 at 4:30 p.m. Eastern Time to discuss its third quarter 2018 financial results (Press release, Genomic Health, OCT 30, 2018, https://www.prnewswire.com/news-releases/genomic-health-to-announce-third-quarter-2018-financial-results-and-host-conference-call-on-tuesday-november-6-2018-300738438.html [SID1234530352]). The call and webcast will follow the release of the third quarter financial results after market close.

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Conference Call Details
To access the live conference call on November 6 at 4:30 p.m. Eastern Time via phone, please dial (877) 303-7208 from the United States and Canada, or +1 (224) 357-2389 internationally. The conference call ID is 9448559. Please dial in approximately ten minutes prior to the start of the call.

To access the live and subsequently archived webcast of the presentation, go to the Investor Relations section of the company’s web site at View Source Please connect to the web site at least 15 minutes prior to the presentation to allow for any software download that may be necessary.

On October 30, 2018 Shanghai Fosun High Technology (Group) Co., Ltd. ("Fosun High Technology"), a subsidiary of Fosun International Limited (the "Company"), which has issued medium-term notes in February 2018, April 2018, July 2018 and September 2018 respectively, and super commercial paper in June 2018 in the China’s interbank bond market, published its 2018 third quarter report (the "Report") on 30 October 2018, in accordance with the relevant regulations in China (Press release, Fosun Pharma, OCT 30, 2018, View Source [SID1234530388]).

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The board of directors of the Company (the "Board") would like to draw the attention of its shareholders and the investment public to the following unaudited principal consolidated financial data of Fosun High Technology for the nine months ended 30 September 2018 as set out below in the Report:

Unit: Thousand Yuan Currency: RMB
As at the end of
this reporting period As at the end of last year
Increase/decrease as at
the end of this reporting
period as compared
with the end of last year
(%)
Total assets 288,748,478 236,798,051 21.94%
Equity attributable to
owners of the parent 53,614,661 50,089,794 7.04%
From the beginning of
2018 up to the end of
this reporting period
From the beginning of
last year up to the end of
the same reporting period
of last year
Increase/decrease as
compared with the
same period of last year
(%)
Revenue from operation 34,250,739 23,433,701 46.16%
Profit attributable to
owners of the parent 3,863,135 3,601,006 7.28%

On October 30, 2018 Syros Pharmaceuticals (NASDAQ: SYRS), a leader in the development of medicines that control the expression of genes, reported that the Company will present data from the dose escalation portion of its Phase 1 trial of SY-1365, its first-in-class selective cyclin-dependent kinase 7 (CDK7) inhibitor, in advanced solid tumor patients in an oral plenary session at the 30th EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Molecular Targets and Cancer Therapeutics Symposium taking place November 13-16 in Dublin (Press release, Syros Pharmaceuticals, OCT 30, 2018, View Source [SID1234530428]). The presentation will include data on safety, pharmacokinetics and proof-of-mechanism. These data will be the first clinical data presented on a selective CDK7 inhibitor, marking a significant milestone in the development of selective CDK7 inhibitors for the treatment of cancer.

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In additional poster presentations, Syros will present new preclinical data on the mechanistic rationale for SY-1365 in combination with carboplatin in ovarian cancer; the first preclinical data on its oral CDK7 inhibitor program; and the discovery of drug targets and patient subsets from its analysis of the super-enhancer landscape in ovarian cancer.

The abstract for the oral presentation on SY-1365 will remain under embargo until the day of the presentation. The abstracts for the poster presentations are now available online on the EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) conference website at View Source

Details on the oral presentation are as follows:

Presentation Title: Proof-of-Mechanism Based on Target Engagement and Modulation of Gene Expression Following Treatment with SY-1365, a First-in-Class Selective CDK7 Inhibitor in Phase 1 Patients with Advanced Cancer
Session Date & Time: Thursday, November 15, 14:30-15:45 GMT (9:30-10:45 a.m. ET)
Presentation Time: 15:30-15:45 GMT (10:30-10:45 a.m. ET)
Session Title: Plenary Session 6: Proffered Papers
Presenter: Dejan Juric, M.D., Massachusetts General Hospital
Abstract Number: 11
Location: Auditorium, The Convention Centre Dublin

Details on the poster presentations are as follows:

Presentation Title: SY-1365, a selective CDK7 inhibitor, enhances carboplatin activity in ovarian cancer cell lines and xenografts, and transcriptionally inhibits homologous recombination repair (HRR) genes
Date & Time: Tuesday, November 13, 12:00-19:00 GMT (7:00 a.m.-2:00 p.m. ET)
Session Title: Poster Session: DNA Repair Modulation
Presenter: Liv Johannessen, Ph.D., Syros
Abstract Number: 50
Location: PB-001, Exhibition Hall, The Convention Centre Dublin

Presentation Title: An oral and selective CDK7 inhibitor demonstrates substantial anti-tumor effect in breast and ovarian cancer models
Date & Time: Tuesday, November 13, from 12:00-19:00 GMT (7:00 a.m.-2:00 p.m. ET)
Session Title: Poster Session: Molecular Targeted Agents – PART 1
Presenter: Claudio Chuaqui, Ph.D., Syros
Abstract Number: 96
Location: PB-047, Exhibition Hall, The Convention Centre Dublin

Presentation Title: Super-enhancer landscapes of ovarian cancer reveal novel epigenomic subtypes and targets
Date & Time: Friday, November 16, from 10:00-14:00 GMT (5:00-9:00 a.m. ET)
Session Title: Poster Session: Molecular Targeted Agents – PART II
Presenter: Matthew Eaton, Ph.D., Syros
Abstract Number: 400
Location: PB-063, Exhibition Hall, The Convention Centre Dublin